Organoid Models of Intestinal Barrier Function: A Review of Physiological Fidelity and Its Limits
DOI:
https://doi.org/10.5281/zenodo.22667238Keywords:
Organoid Models of Intestinal Barrier Function; Biological sciences; Evidence synthesis; Reproducibility; Research methodologyAbstract
Organoid Models of Intestinal Barrier Function has moved quickly from a niche research question to something a wider
community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We pull
together the current evidence for organoid models of intestinal barrier function, covering the methodological, practical,
regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers and reviewers are still
largely working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered here
than either broad rollout or blanket avoidance.
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