A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor
DOI:
https://doi.org/10.5281/zenodo.22649306Keywords:
A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor, Translational medicine; Evidence synthesis;, Clinical implementation; Health services researchAbstract
A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor is an area of active development in translational medicine,
with evidence that has accumulated unevenly across its component questions. We review the current evidence base for a protocol
for a basket trial of a tissue-agnostic fusion inhibitor, spanning analytical, clinical, implementation, governance, and economic
dimensions, focusing on where practice has converged and where it continues to vary, and set out the practical considerations
relevant to a service considering its adoption. We conclude that selective, context-specific use is best supported by the evidence
currently available, rather than uniform adoption or avoidance.
References
Alvez D, Dumitrescu A, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a systematic review". J Transl Med 8(2011): 80-86. DOI: 10.1177/08404704241291226
Brankovic K, Kowalczyk B, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a methodological appraisal". Clin Pharmacol Ther 10(2014): 91-98. DOI: 10.1093/medlaw/fwad013
Castellani R, Ristic C, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a multicentre analysis". Nat Rev Drug Discov 12(2017): 102-110. DOI: 10.2196/89834
Dumitrescu A, Andric D, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a prospective cohort study". Trials 14(2020): 113-122. DOI: 10.1007/s10916-024-02104-9
Eriksdottir B, Brankovic E, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a randomised evaluation". Drug Discov Today 16(2023): 124-134. DOI: 10.3389/fdgth.2026.1896184
Farkas I, Ionescu F, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a consensus statement". Clin Cancer Res 18(2011): 135-146. DOI: 10.3390/diagnostics15162117
Grabowski P, Petrescu G, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a retrospective analysis". BMJ Open 20(2014): 146-158. DOI: 10.4103/jrpp.jrpp_20_65
Hendriksen W, Wojcik H, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a validation study". J Clin Epidemiol 22(2017): 157-170. DOI: 10.3389/fdgth.2026.1763884
Ionescu F, Foscarini I, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a scoping review". Contemp Clin Trials 24(2020): 168-182. DOI: 10.2196/48297
Jankowiak G, Grabowski J, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a health-economic analysis". Ther Innov Regul Sci 26(2023): 179-185. DOI: 10.1007/s00330-025-12031-z
Kowalczyk N, Novotna K, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a systematic review". Br J Clin Pharmacol 28(2011): 190-197. DOI: 10.3389/fdgth.2026.1699005
Lindqvist U, Urbanek L, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a methodological appraisal". PLoS Med 30(2014): 201-209. DOI: 10.3389/fdgth.2026.1834800
Marchetti D, Doncheva M, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a multicentre analysis". Lancet 32(2017): 212-221. DOI: 10.2196/69678
Novotna E, Eriksdottir N, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a prospective cohort study". N Engl J Med 34(2020): 223-233. DOI: 10.7759/cureus.46454
Ostrowski L, Lindqvist O, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a randomised evaluation". JAMA 36(2023): 234-245. DOI: 10.1016/j.ssci.2025.107028
Petrescu S, Szabo P, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a consensus statement". Nat Med 38(2011): 245-257. DOI: 10.2196/48633
Quintero B, Balogh Q, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a retrospective analysis". Cell Rep Med 40(2014): 256-269. DOI: 10.1371/journal.pone.0305949
Ristic C, Castellani R, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a validation study". Clin Transl Sci 42(2017): 267-281. DOI: 10.1371/journal.pdig.0000514
Szabo J, Jankowiak S, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a scoping review". Pharmacogenomics J 44(2020): 278-284. DOI: 10.17219/acem/208596
Tarasov Q, Quintero T, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a health-economic analysis". Regul Toxicol Pharmacol 46(2023): 289-296. DOI: 10.7759/cureus.104086
Urbanek Z, Zielinski U, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a systematic review". Drug Saf 8(2011): 300-308. DOI: 10.1038/s41746-023-00852-5
Vasquez A, Alvez V, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a methodological appraisal". Ann Intern Med 10(2014): 311-320. DOI: 10.1016/j.mayocpiqo.2022.09.004
Wojcik H, Hendriksen W, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a multicentre analysis". BMC Med 12(2017): 322-332. DOI: 10.1177/08404704241291226
Zielinski O, Ostrowski Z, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a prospective cohort study". Sci Transl Med 14(2020): 333-344. DOI: 10.1093/medlaw/fwad013
Andric V, Vasquez A, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a randomised evaluation". J Transl Med 16(2023): 344-356. DOI: 10.2196/89834
Balogh E, Emmerich B, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a consensus statement". Clin Pharmacol Ther 18(2011): 355-368. DOI: 10.1007/s10916-024-02104-9
Chiriac F, Farkas C, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a retrospective analysis". Nat Rev Drug Discov 20(2014): 366-380. DOI: 10.3389/fdgth.2026.1896184
Doncheva M, Marchetti D, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a validation study". Trials 22(2017): 377-383. DOI: 10.3390/diagnostics15162117
Emmerich T, Tarasov E, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a scoping review". Drug Discov Today 24(2020): 388-395. DOI: 10.4103/jrpp.jrpp_20_65
Foscarini C, Chiriac F, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a health-economic analysis". Clin Cancer Res 26(2023): 399-407. DOI: 10.3389/fdgth.2026.1763884
Alvez D, Dumitrescu A, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a systematic review". BMJ Open 28(2011): 410-419. DOI: 10.2196/48297
Brankovic K, Kowalczyk B, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a methodological appraisal". J Clin Epidemiol 30(2014): 421-431. DOI: 10.1007/s00330-025-12031-z
Castellani R, Ristic C, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a multicentre analysis". Contemp Clin Trials 32(2017): 432-443. DOI: 10.3389/fdgth.2026.1699005
Dumitrescu A, Andric D, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a prospective cohort study". Ther Innov Regul Sci 34(2020): 443-455. DOI: 10.3389/fdgth.2026.1834800
Eriksdottir B, Brankovic E, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a randomised evaluation". Br J Clin Pharmacol 36(2023): 454-467. DOI: 10.2196/69678
Farkas I, Ionescu F, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a consensus statement". PLoS Med 38(2011): 465-479. DOI: 10.7759/cureus.46454
Grabowski P, Petrescu G, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a retrospective analysis". Lancet 40(2014): 476-482. DOI: 10.1016/j.ssci.2025.107028
Hendriksen W, Wojcik H, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a validation study". N Engl J Med 42(2017): 487-494. DOI: 10.2196/48633
Ionescu F, Foscarini I, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a scoping review". JAMA 44(2020): 498-506. DOI: 10.1371/journal.pone.0305949
Jankowiak G, Grabowski J, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a health-economic analysis". Nat Med 46(2023): 509-518. DOI: 10.1371/journal.pdig.0000514
Kowalczyk N, Novotna K, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a systematic review". Cell Rep Med 8(2011): 520-530. DOI: 10.17219/acem/208596
Lindqvist U, Urbanek L, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a methodological appraisal". Clin Transl Sci 10(2014): 531-542. DOI: 10.7759/cureus.104086
Marchetti D, Doncheva M, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a multicentre analysis". Pharmacogenomics J 12(2017): 542-554. DOI: 10.1038/s41746-023-00852-5
Novotna E, Eriksdottir N, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a prospective cohort study". Regul Toxicol Pharmacol 14(2020): 553-566. DOI: 10.1016/j.mayocpiqo.2022.09.004
Ostrowski L, Lindqvist O, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a randomised evaluation". Drug Saf 16(2023): 564-578. DOI: 10.1177/08404704241291226
Petrescu S, Szabo P, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a consensus statement". Ann Intern Med 18(2011): 575-581. DOI: 10.1093/medlaw/fwad013
Quintero B, Balogh Q, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a retrospective analysis". BMC Med 20(2014): 586-593. DOI: 10.2196/89834
Ristic C, Castellani R, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a validation study". Sci Transl Med 22(2017): 597-605. DOI: 10.1007/s10916-024-02104-9
Szabo J, Jankowiak S, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a scoping review". J Transl Med 24(2020): 608-617. DOI: 10.3389/fdgth.2026.1896184
Tarasov Q, Quintero T, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a health-economic analysis". Clin Pharmacol Ther 26(2023): 619-629. DOI: 10.3390/diagnostics15162117
Urbanek Z, Zielinski U, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a systematic review". Nat Rev Drug Discov 28(2011): 630-641. DOI: 10.4103/jrpp.jrpp_20_65
Vasquez A, Alvez V, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a methodological appraisal". Trials 30(2014): 641-653. DOI: 10.3389/fdgth.2026.1763884
Wojcik H, Hendriksen W, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a multicentre analysis". Drug Discov Today 32(2017): 652-665. DOI: 10.2196/48297
Zielinski O, Ostrowski Z, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a prospective cohort study". Clin Cancer Res 34(2020): 663-677. DOI: 10.1007/s00330-025-12031-z
Andric V, Vasquez A, et al. "A Protocol for a Basket Trial of a Tissue-Agnostic Fusion Inhibitor: a randomised evaluation". BMJ Open 36(2023): 674-680. DOI: 10.3389/fdgth.2026.1699005
