Artificial Intelligence Generated Molecules Entering Trials: Provenance, Novelty and Attribution

Authors

  • Reinier Aalderink Centre for Computational Drug Discovery, Bommelerwaard Centre for Experimental Therapeutics, Zaltbommel, Netherlands Author
  • Sigrun Thorgilsson Centre for Regulatory Science, Arnessysla Institute of Translational Medicine, Hveragerdi, Iceland Author
  • Barbora Zemanek Centre for Research Ethics, Polabina Institute of Translational Medicine, Podebrady, Czech Republic Author

DOI:

https://doi.org/10.5281/zenodo.22649409

Keywords:

Artificial Intelligence Generated Molecules Entering Trials;, Translational medicine; Evidence synthesis, Clinical implementation; Health services research

Abstract

Artificial Intelligence Generated Molecules Entering Trials is an area of active development in translational medicine, with
evidence that has accumulated unevenly across its component questions. We review the current evidence base for artificial
intelligence generated molecules entering trials, spanning analytical, clinical, implementation, governance, and economic
dimensions, focusing on where practice has converged and where it continues to vary, and set out the practical considerations
relevant to a service considering its adoption. We conclude that selective, context-specific use is best supported by the evidence
currently available, rather than uniform adoption or avoidance.

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Eriksdottir B, Brankovic E, et al. "Artificial Intelligence Generated Molecules Entering Trials: a randomised evaluation". Br J Clin Pharmacol 36(2023): 454-467. DOI: 10.2196/48633

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Hendriksen W, Wojcik H, et al. "Artificial Intelligence Generated Molecules Entering Trials: a validation study". N Engl J Med 42(2017): 487-494. DOI: 10.17219/acem/208596

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Published

2025-07-11

How to Cite

Artificial Intelligence Generated Molecules Entering Trials: Provenance, Novelty and Attribution. (2025). Translational Medicine & Therapeutics Journal, 4(2), 55-63. https://doi.org/10.5281/zenodo.22649409

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