Dose Individualisation Using Model-Informed Precision Dosing: Implementation Outside Research Settings
DOI:
https://doi.org/10.5281/zenodo.22649548Keywords:
Dose Individualisation Using Model-Informed Precision Dosing;, Translational medicine; Evidence synthesis;, Clinical implementation; Health services researchAbstract
Dose Individualisation Using Model-Informed Precision Dosing is an area of active development in translational medicine, with
evidence that has accumulated unevenly across its component questions. We review the current evidence base for dose
individualisation using model-informed precision dosing, spanning analytical, clinical, implementation, governance, and
economic dimensions, focusing on where practice has converged and where it continues to vary, and set out the practical
considerations relevant to a service considering its adoption. We conclude that selective, context-specific use is best supported by
the evidence currently available, rather than uniform adoption or avoidance.
References
Alvez D, Dumitrescu A, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a systematic review". J Transl Med 8(2011): 80-86. DOI: 10.2196/69678
Brankovic K, Kowalczyk B, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a methodological appraisal". Clin Pharmacol Ther 10(2014): 91-98. DOI: 10.7759/cureus.46454
Castellani R, Ristic C, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a multicentre analysis". Nat Rev Drug Discov 12(2017): 102-110. DOI: 10.1016/j.ssci.2025.107028
Dumitrescu A, Andric D, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a prospective cohort study". Trials 14(2020): 113-122. DOI: 10.2196/48633
Eriksdottir B, Brankovic E, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a randomised evaluation". Drug Discov Today 16(2023): 124-134. DOI: 10.1371/journal.pone.0305949
Farkas I, Ionescu F, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a consensus statement". Clin Cancer Res 18(2011): 135-146. DOI: 10.1371/journal.pdig.0000514
Grabowski P, Petrescu G, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a retrospective analysis". BMJ Open 20(2014): 146-158. DOI: 10.17219/acem/208596
Hendriksen W, Wojcik H, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a validation study". J Clin Epidemiol 22(2017): 157-170. DOI: 10.7759/cureus.104086
Ionescu F, Foscarini I, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a scoping review". Contemp Clin Trials 24(2020): 168-182. DOI: 10.1038/s41746-023-00852-5
Jankowiak G, Grabowski J, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a health-economic analysis". Ther Innov Regul Sci 26(2023): 179-185. DOI: 10.1016/j.mayocpiqo.2022.09.004
Kowalczyk N, Novotna K, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a systematic review". Br J Clin Pharmacol 28(2011): 190-197. DOI: 10.1177/08404704241291226
Lindqvist U, Urbanek L, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a methodological appraisal". PLoS Med 30(2014): 201-209. DOI: 10.1093/medlaw/fwad013
Marchetti D, Doncheva M, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a multicentre analysis". Lancet 32(2017): 212-221. DOI: 10.2196/89834
Novotna E, Eriksdottir N, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a prospective cohort study". N Engl J Med 34(2020): 223-233. DOI: 10.1007/s10916-024-02104-9
Ostrowski L, Lindqvist O, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a randomised evaluation". JAMA 36(2023): 234-245. DOI: 10.3389/fdgth.2026.1896184
Petrescu S, Szabo P, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a consensus statement". Nat Med 38(2011): 245-257. DOI: 10.3390/diagnostics15162117
Quintero B, Balogh Q, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a retrospective analysis". Cell Rep Med 40(2014): 256-269. DOI: 10.4103/jrpp.jrpp_20_65
Ristic C, Castellani R, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a validation study". Clin Transl Sci 42(2017): 267-281. DOI: 10.3389/fdgth.2026.1763884
Szabo J, Jankowiak S, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a scoping review". Pharmacogenomics J 44(2020): 278-284. DOI: 10.2196/48297
Tarasov Q, Quintero T, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a health-economic analysis". Regul Toxicol Pharmacol 46(2023): 289-296. DOI: 10.1007/s00330-025-12031-z
Urbanek Z, Zielinski U, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a systematic review". Drug Saf 8(2011): 300-308. DOI: 10.3389/fdgth.2026.1699005
Vasquez A, Alvez V, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a methodological appraisal". Ann Intern Med 10(2014): 311-320. DOI: 10.3389/fdgth.2026.1834800
Wojcik H, Hendriksen W, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a multicentre analysis". BMC Med 12(2017): 322-332. DOI: 10.2196/69678
Zielinski O, Ostrowski Z, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a prospective cohort study". Sci Transl Med 14(2020): 333-344. DOI: 10.7759/cureus.46454
Andric V, Vasquez A, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a randomised evaluation". J Transl Med 16(2023): 344-356. DOI: 10.1016/j.ssci.2025.107028
Balogh E, Emmerich B, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a consensus statement". Clin Pharmacol Ther 18(2011): 355-368. DOI: 10.2196/48633
Chiriac F, Farkas C, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a retrospective analysis". Nat Rev Drug Discov 20(2014): 366-380. DOI: 10.1371/journal.pone.0305949
Doncheva M, Marchetti D, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a validation study". Trials 22(2017): 377-383. DOI: 10.1371/journal.pdig.0000514
Emmerich T, Tarasov E, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a scoping review". Drug Discov Today 24(2020): 388-395. DOI: 10.17219/acem/208596
Foscarini C, Chiriac F, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a health-economic analysis". Clin Cancer Res 26(2023): 399-407. DOI: 10.7759/cureus.104086
Alvez D, Dumitrescu A, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a systematic review". BMJ Open 28(2011): 410-419. DOI: 10.1038/s41746-023-00852-5
Brankovic K, Kowalczyk B, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a methodological appraisal". J Clin Epidemiol 30(2014): 421-431. DOI: 10.1016/j.mayocpiqo.2022.09.004
Castellani R, Ristic C, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a multicentre analysis". Contemp Clin Trials 32(2017): 432-443. DOI: 10.1177/08404704241291226
Dumitrescu A, Andric D, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a prospective cohort study". Ther Innov Regul Sci 34(2020): 443-455. DOI: 10.1093/medlaw/fwad013
Eriksdottir B, Brankovic E, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a randomised evaluation". Br J Clin Pharmacol 36(2023): 454-467. DOI: 10.2196/89834
Farkas I, Ionescu F, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a consensus statement". PLoS Med 38(2011): 465-479. DOI: 10.1007/s10916-024-02104-9
Grabowski P, Petrescu G, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a retrospective analysis". Lancet 40(2014): 476-482. DOI: 10.3389/fdgth.2026.1896184
Hendriksen W, Wojcik H, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a validation study". N Engl J Med 42(2017): 487-494. DOI: 10.3390/diagnostics15162117
Ionescu F, Foscarini I, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a scoping review". JAMA 44(2020): 498-506. DOI: 10.4103/jrpp.jrpp_20_65
Jankowiak G, Grabowski J, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a health-economic analysis". Nat Med 46(2023): 509-518. DOI: 10.3389/fdgth.2026.1763884
Kowalczyk N, Novotna K, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a systematic review". Cell Rep Med 8(2011): 520-530. DOI: 10.2196/48297
Lindqvist U, Urbanek L, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a methodological appraisal". Clin Transl Sci 10(2014): 531-542. DOI: 10.1007/s00330-025-12031-z
Marchetti D, Doncheva M, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a multicentre analysis". Pharmacogenomics J 12(2017): 542-554. DOI: 10.3389/fdgth.2026.1699005
Novotna E, Eriksdottir N, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a prospective cohort study". Regul Toxicol Pharmacol 14(2020): 553-566. DOI: 10.3389/fdgth.2026.1834800
Ostrowski L, Lindqvist O, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a randomised evaluation". Drug Saf 16(2023): 564-578. DOI: 10.2196/69678
Petrescu S, Szabo P, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a consensus statement". Ann Intern Med 18(2011): 575-581. DOI: 10.7759/cureus.46454
Quintero B, Balogh Q, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a retrospective analysis". BMC Med 20(2014): 586-593. DOI: 10.1016/j.ssci.2025.107028
Ristic C, Castellani R, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a validation study". Sci Transl Med 22(2017): 597-605. DOI: 10.2196/48633
Szabo J, Jankowiak S, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a scoping review". J Transl Med 24(2020): 608-617. DOI: 10.1371/journal.pone.0305949
Tarasov Q, Quintero T, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a health-economic analysis". Clin Pharmacol Ther 26(2023): 619-629. 10.1371/journal.pdig.0000514
Urbanek Z, Zielinski U, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a systematic review". Nat Rev Drug Discov 28(2011): 630-641. DOI: 10.17219/acem/208596
Vasquez A, Alvez V, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a methodological appraisal". Trials 30(2014): 641-653. DOI: 10.7759/cureus.104086
Wojcik H, Hendriksen W, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a multicentre analysis". Drug Discov Today 32(2017): 652-665. 10.1038/s41746-023-00852-5
Zielinski O, Ostrowski Z, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a prospective cohort study". Clin Cancer Res 34(2020): 663-677. 10.1016/j.mayocpiqo.2022.09.004
Andric V, Vasquez A, et al. "Dose Individualisation Using Model-Informed Precision Dosing: a randomised evaluation". BMJ Open 36(2023): 674-680. DOI: 10.1177/08404704241291226
