Senolytic Therapeutics: Translating a Compelling Mouse Phenotype Into a Testable Human Endpoint
DOI:
https://doi.org/10.5281/zenodo.22649028Keywords:
Senolytic Therapeutics; Translational medicine;, Evidence synthesis; Clinical implementation;, Health services researchAbstract
Senolytic Therapeutics is an area of active development in translational medicine, with evidence that has accumulated unevenly
across its component questions. We review the current evidence base for senolytic therapeutics, spanning analytical, clinical,
implementation, governance, and economic dimensions, focusing on where practice has converged and where it continues to vary,
and set out the practical considerations relevant to a service considering its adoption. We conclude that selective, context-specific
use is best supported by the evidence currently available, rather than uniform adoption or avoidance.
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