Antibody-Drug Conjugate Payload Chemistry and Off-Target Toxicity: Mapping Class Effects to Organ Systems
DOI:
https://doi.org/10.5281/zenodo.22649076Keywords:
Antibody-Drug Conjugate Payload Chemistry and Off-Target Toxicity;, Translational medicine; Evidence synthesis;, Clinical implementation; Health services researchAbstract
Antibody-Drug Conjugate Payload Chemistry and Off-Target Toxicity is an area of active development in translational medicine,
with evidence that has accumulated unevenly across its component questions. We review the current evidence base for
antibody-drug conjugate payload chemistry and off-target toxicity, spanning analytical, clinical, implementation, governance, and
economic dimensions, focusing on where practice has converged and where it continues to vary, and set out the practical
considerations relevant to a service considering its adoption. We conclude that selective, context-specific use is best supported by
the evidence currently available, rather than uniform adoption or avoidance
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