Allometric Scaling From Animal to First Human Dose: How Often the Prediction Is Wrong and In Which Direction
DOI:
https://doi.org/10.5281/zenodo.22649232Keywords:
Allometric Scaling From Animal to First Human Dose;, Translational medicine; Evidence synthesis;, Clinical implementation; Health services researchAbstract
Allometric Scaling From Animal to First Human Dose is an area of active development in translational medicine, with evidence
that has accumulated unevenly across its component questions. We review the current evidence base for allometric scaling from
animal to first human dose, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing on
where practice has converged and where it continues to vary, and set out the practical considerations relevant to a service
considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently available,
rather than uniform adoption or avoidance.
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