Precision Oncology Molecular Tumour Boards: Recommendation Rates, Access and Outcome Attribution
DOI:
https://doi.org/10.5281/zenodo.22649281Keywords:
Precision Oncology Molecular Tumour Boards;, Translational medicine; Evidence synthesis, Clinical implementation; Health services researchAbstract
Precision Oncology Molecular Tumour Boards is an area of active development in translational medicine, with evidence that has
accumulated unevenly across its component questions. We review the current evidence base for precision oncology molecular
tumour boards, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing on where practice
has converged and where it continues to vary, and set out the practical considerations relevant to a service considering its
adoption. We conclude that selective, context-specific use is best supported by the evidence currently available, rather than
uniform adoption or avoidance.
References
Alvez D, Dumitrescu A, et al. "Precision Oncology Molecular Tumour Boards: a systematic review". J Transl Med 8(2011): 80-86. DOI: 10.17219/acem/208596
Brankovic K, Kowalczyk B, et al. "Precision Oncology Molecular Tumour Boards: a methodological appraisal". Clin Pharmacol Ther 10(2014): 91-98. DOI: 10.7759/cureus.104086
Castellani R, Ristic C, et al. "Precision Oncology Molecular Tumour Boards: a multicentre analysis". Nat Rev Drug Discov 12(2017): 102-110. DOI: 10.1038/s41746-023-00852-5
Dumitrescu A, Andric D, et al. "Precision Oncology Molecular Tumour Boards: a prospective cohort study". Trials 14(2020): 113-122. DOI: 10.1016/j.mayocpiqo.2022.09.004
Eriksdottir B, Brankovic E, et al. "Precision Oncology Molecular Tumour Boards: a randomised evaluation". Drug Discov Today 16(2023): 124-134. DOI: 10.1177/08404704241291226
Farkas I, Ionescu F, et al. "Precision Oncology Molecular Tumour Boards: a consensus statement". Clin Cancer Res 18(2011): 135-146. DOI: 10.1093/medlaw/fwad013
Grabowski P, Petrescu G, et al. "Precision Oncology Molecular Tumour Boards: a retrospective analysis". BMJ Open 20(2014): 146-158. DOI: 10.2196/89834
Hendriksen W, Wojcik H, et al. "Precision Oncology Molecular Tumour Boards: a validation study". J Clin Epidemiol 22(2017): 157-170. DOI: 10.1007/s10916-024-02104-9
Ionescu F, Foscarini I, et al. "Precision Oncology Molecular Tumour Boards: a scoping review". Contemp Clin Trials 24(2020): 168-182. DOI: 10.3389/fdgth.2026.1896184
Jankowiak G, Grabowski J, et al. "Precision Oncology Molecular Tumour Boards: a health-economic analysis". Ther Innov Regul Sci 26(2023): 179-185. DOI: 10.3390/diagnostics15162117
Kowalczyk N, Novotna K, et al. "Precision Oncology Molecular Tumour Boards: a systematic review". Br J Clin Pharmacol 28(2011): 190-197. DOI: 10.4103/jrpp.jrpp_20_65
Lindqvist U, Urbanek L, et al. "Precision Oncology Molecular Tumour Boards: a methodological appraisal". PLoS Med 30(2014): 201-209. DOI: 10.3389/fdgth.2026.1763884
Marchetti D, Doncheva M, et al. "Precision Oncology Molecular Tumour Boards: a multicentre analysis". Lancet 32(2017): 212-221. DOI: 10.2196/48297
Novotna E, Eriksdottir N, et al. "Precision Oncology Molecular Tumour Boards: a prospective cohort study". N Engl J Med 34(2020): 223-233. DOI: 10.1007/s00330-025-12031-z
Ostrowski L, Lindqvist O, et al. "Precision Oncology Molecular Tumour Boards: a randomised evaluation". JAMA 36(2023): 234-245. DOI: 10.3389/fdgth.2026.1699005
Petrescu S, Szabo P, et al. "Precision Oncology Molecular Tumour Boards: a consensus statement". Nat Med 38(2011): 245-257. DOI: 10.3389/fdgth.2026.1834800
Quintero B, Balogh Q, et al. "Precision Oncology Molecular Tumour Boards: a retrospective analysis". Cell Rep Med 40(2014): 256-269. DOI: 10.2196/69678
Ristic C, Castellani R, et al. "Precision Oncology Molecular Tumour Boards: a validation study". Clin Transl Sci 42(2017): 267-281. DOI: 10.7759/cureus.46454
Szabo J, Jankowiak S, et al. "Precision Oncology Molecular Tumour Boards: a scoping review". Pharmacogenomics J 44(2020): 278-284. DOI: 10.1016/j.ssci.2025.107028
Tarasov Q, Quintero T, et al. "Precision Oncology Molecular Tumour Boards: a health-economic analysis". Regul Toxicol Pharmacol 46(2023): 289-296. DOI: 10.2196/48633
Urbanek Z, Zielinski U, et al. "Precision Oncology Molecular Tumour Boards: a systematic review". Drug Saf 8(2011): 300-308. DOI: 10.1371/journal.pone.0305949
Vasquez A, Alvez V, et al. "Precision Oncology Molecular Tumour Boards: a methodological appraisal". Ann Intern Med 10(2014): 311-320. DOI: 10.1371/journal.pdig.0000514
Wojcik H, Hendriksen W, et al. "Precision Oncology Molecular Tumour Boards: a multicentre analysis". BMC Med 12(2017): 322-332. DOI: 10.17219/acem/208596
Zielinski O, Ostrowski Z, et al. "Precision Oncology Molecular Tumour Boards: a prospective cohort study". Sci Transl Med 14(2020): 333-344. DOI: 10.7759/cureus.104086
Andric V, Vasquez A, et al. "Precision Oncology Molecular Tumour Boards: a randomised evaluation". J Transl Med 16(2023): 344-356. DOI: 10.1038/s41746-023-00852-5
Balogh E, Emmerich B, et al. "Precision Oncology Molecular Tumour Boards: a consensus statement". Clin Pharmacol Ther 18(2011): 355-368. DOI: 10.1016/j.mayocpiqo.2022.09.004
Chiriac F, Farkas C, et al. "Precision Oncology Molecular Tumour Boards: a retrospective analysis". Nat Rev Drug Discov 20(2014): 366-380. DOI: 10.1177/08404704241291226
Doncheva M, Marchetti D, et al. "Precision Oncology Molecular Tumour Boards: a validation study". Trials 22(2017): 377-383. DOI: 10.1093/medlaw/fwad013
Emmerich T, Tarasov E, et al. "Precision Oncology Molecular Tumour Boards: a scoping review". Drug Discov Today 24(2020): 388-395. DOI: 10.2196/89834
Foscarini C, Chiriac F, et al. "Precision Oncology Molecular Tumour Boards: a health-economic analysis". Clin Cancer Res 26(2023): 399-407. DOI: 10.1007/s10916-024-02104-9
Alvez D, Dumitrescu A, et al. "Precision Oncology Molecular Tumour Boards: a systematic review". BMJ Open 28(2011): 410-419. DOI: 10.3389/fdgth.2026.1896184
Brankovic K, Kowalczyk B, et al. "Precision Oncology Molecular Tumour Boards: a methodological appraisal". J Clin Epidemiol 30(2014): 421-431. DOI: 10.3390/diagnostics15162117
Castellani R, Ristic C, et al. "Precision Oncology Molecular Tumour Boards: a multicentre analysis". Contemp Clin Trials 32(2017): 432-443. DOI: 10.4103/jrpp.jrpp_20_65
Dumitrescu A, Andric D, et al. "Precision Oncology Molecular Tumour Boards: a prospective cohort study". Ther Innov Regul Sci 34(2020): 443-455. DOI: 10.3389/fdgth.2026.1763884
Eriksdottir B, Brankovic E, et al. "Precision Oncology Molecular Tumour Boards: a randomised evaluation". Br J Clin Pharmacol 36(2023): 454-467. DOI: 10.2196/48297
Farkas I, Ionescu F, et al. "Precision Oncology Molecular Tumour Boards: a consensus statement". PLoS Med 38(2011): 465-479. DOI: 10.1007/s00330-025-12031-z
Grabowski P, Petrescu G, et al. "Precision Oncology Molecular Tumour Boards: a retrospective analysis". Lancet 40(2014): 476-482. DOI: 10.3389/fdgth.2026.1699005
Hendriksen W, Wojcik H, et al. "Precision Oncology Molecular Tumour Boards: a validation study". N Engl J Med 42(2017): 487-494. DOI: 10.3389/fdgth.2026.1834800
Ionescu F, Foscarini I, et al. "Precision Oncology Molecular Tumour Boards: a scoping review". JAMA 44(2020): 498-506. DOI: 10.2196/69678
Jankowiak G, Grabowski J, et al. "Precision Oncology Molecular Tumour Boards: a health-economic analysis". Nat Med 46(2023): 509-518. DOI: 10.7759/cureus.46454
Kowalczyk N, Novotna K, et al. "Precision Oncology Molecular Tumour Boards: a systematic review". Cell Rep Med 8(2011): 520-530. DOI: 10.1016/j.ssci.2025.107028
Lindqvist U, Urbanek L, et al. "Precision Oncology Molecular Tumour Boards: a methodological appraisal". Clin Transl Sci 10(2014): 531-542. DOI: 10.2196/48633
Marchetti D, Doncheva M, et al. "Precision Oncology Molecular Tumour Boards: a multicentre analysis". Pharmacogenomics J 12(2017): 542-554. DOI: 10.1371/journal.pone.0305949
Novotna E, Eriksdottir N, et al. "Precision Oncology Molecular Tumour Boards: a prospective cohort study". Regul Toxicol Pharmacol 14(2020): 553-566. DOI: 10.1371/journal.pdig.0000514
Ostrowski L, Lindqvist O, et al. "Precision Oncology Molecular Tumour Boards: a randomised evaluation". Drug Saf 16(2023): 564-578. DOI: 10.17219/acem/208596
Petrescu S, Szabo P, et al. "Precision Oncology Molecular Tumour Boards: a consensus statement". Ann Intern Med 18(2011): 575-581. DOI: 10.7759/cureus.104086
Quintero B, Balogh Q, et al. "Precision Oncology Molecular Tumour Boards: a retrospective analysis". BMC Med 20(2014): 586-593. DOI: 10.1038/s41746-023-00852-5
Ristic C, Castellani R, et al. "Precision Oncology Molecular Tumour Boards: a validation study". Sci Transl Med 22(2017): 597-605. DOI: 10.1016/j.mayocpiqo.2022.09.004
Szabo J, Jankowiak S, et al. "Precision Oncology Molecular Tumour Boards: a scoping review". J Transl Med 24(2020): 608-617. DOI: 10.1177/08404704241291226
Tarasov Q, Quintero T, et al. "Precision Oncology Molecular Tumour Boards: a health-economic analysis". Clin Pharmacol Ther 26(2023): 619-629. DOI: 10.1093/medlaw/fwad013
Urbanek Z, Zielinski U, et al. "Precision Oncology Molecular Tumour Boards: a systematic review". Nat Rev Drug Discov 28(2011): 630-641. DOI: 10.2196/89834
Vasquez A, Alvez V, et al. "Precision Oncology Molecular Tumour Boards: a methodological appraisal". Trials 30(2014): 641-653. DOI: 10.1007/s10916-024-02104-9
Wojcik H, Hendriksen W, et al. "Precision Oncology Molecular Tumour Boards: a multicentre analysis". Drug Discov Today 32(2017): 652-665. DOI: 10.3389/fdgth.2026.1896184
Zielinski O, Ostrowski Z, et al. "Precision Oncology Molecular Tumour Boards: a prospective cohort study". Clin Cancer Res 34(2020): 663-677. DOI: 10.3390/diagnostics15162117
Andric V, Vasquez A, et al. "Precision Oncology Molecular Tumour Boards: a randomised evaluation". BMJ Open 36(2023): 674-680. DOI: 10.4103/jrpp.jrpp_20_65
