CRISPR Base Editing for a Monogenic Liver Disorder: Off-Target Assessment and Long-Term Follow-Up Obligations
DOI:
https://doi.org/10.5281/zenodo.22649285Keywords:
CRISPR Base Editing for a Monogenic Liver Disorder;, Translational medicine; Evidence synthesis, Clinical implementation; Health services researchAbstract
CRISPR Base Editing for a Monogenic Liver Disorder is an area of active development in translational medicine, with evidence
that has accumulated unevenly across its component questions. We review the current evidence base for crispr base editing for a
monogenic liver disorder, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing on
where practice has converged and where it continues to vary, and set out the practical considerations relevant to a service
considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently available,
rather than uniform adoption or avoidance.
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