Precision Fermentation of Dairy Proteins: A Review of Strain Development, Yield and Regulatory Route

Authors

  • Erwin Fluckiger Centre for Industrial Biotechnology, Emmental Institute of Agricultural Biotechnology, Langnau, Switzerland Author
  • Carsten Enevoldsen Centre for Industrial Biotechnology, Samso Centre for Plant Genome Engineering, Tranebjerg, Denmark Author
  • Isidor Bruckmoser Centre for Regulatory Science, Sudburgenland Institute of Agricultural Biotechnology, Oberwart, Austria Author

DOI:

https://doi.org/10.5281/zenodo.22666400

Keywords:

Precision Fermentation of Dairy Proteins; Agricultural biotechnology; Gene editing; Evidence synthesis; Biosafety regulation

Abstract

There is real interest in precision fermentation of dairy proteins right now, and real uncertainty about exactly where it delivers the
most value. We pull together the current evidence for precision fermentation of dairy proteins, covering the methodological,
practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers and regulators
are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered
here than either broad rollout or blanket avoidance.

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Grabowski P, Petrescu G, et al. "Precision Fermentation of Dairy Proteins: a case study". Nat Biotechnol 40(2014): 476-482. DOI: 10.1177/08404704241291226

Hendriksen W, Wojcik H, et al. "Precision Fermentation of Dairy Proteins: a meta-analysis". Sci Rep 42(2017): 487-494. DOI: 10.1093/medlaw/fwad013

Ionescu F, Foscarini I, et al. "Precision Fermentation of Dairy Proteins: a comparative trial". PLoS One 44(2020): 498-506. DOI: 10.2196/89834

Jankowiak G, Grabowski J, et al. "Precision Fermentation of Dairy Proteins: a stakeholder-survey study". BMC Plant Biol 46(2023): 509-518. DOI: 10.1007/s10916-024-02104-9

Kowalczyk N, Novotna K, et al. "Precision Fermentation of Dairy Proteins: a field trial". Biotechnol Adv 8(2014): 520-530. DOI: 10.3389/fdgth.2026.1896184

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Published

2022-11-28