Multiplex Editing for Quantitative Trait Modification: How Many Loci Before Fitness Costs Appear

Abstract

Multiplex Editing for Quantitative Trait Modification has moved quickly from a research idea to something a working breeding or
production programme can actually use, but the evidence behind it has not always kept pace. We pull together the current
evidence for multiplex editing for quantitative trait modification, covering the methodological, practical, regulatory and cost
angles, with an eye on where practice has genuinely settled and where researchers and regulators are still largely working it out
for themselves. Selective, context-specific adoption looks better supported by the evidence gathered here than either broad rollout
or blanket avoidance.