Tumour-Adjacent Normal Tissue as a Reference: A Case Study of Molecular Field Effects
DOI:
https://doi.org/10.5281/zenodo.22668135Keywords:
Tumour-Adjacent Normal Tissue as a Reference; Biological sciences; Evidence synthesis; Reproducibility; Research methodologyAbstract
There is real interest in tumour-adjacent normal tissue as a reference right now, and real uncertainty about exactly where it
delivers the most value. We pull together the current evidence for tumour-adjacent normal tissue as a reference, covering the
methodological, practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers
and reviewers are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the
evidence gathered here than either broad rollout or blanket avoidance.
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