Structural Basis of Substrate Selectivity in a Transporter Family: Cryo-EM at Multiple States

Abstract

Structural Basis of Substrate Selectivity in a Transporter Family has moved quickly from a niche research question to something a
wider community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We pull
together the current evidence for structural basis of substrate selectivity in a transporter family, covering the methodological,
practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers and reviewers
are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered
here than either broad rollout or blanket avoidance.