Circadian Control of Metabolic Gene Expression: A Review of Tissue-Specific Divergence

Authors

  • Ilona-M Detre Department of Chronobiology, Bukk Institute of Biological Sciences, Miskolc, Hungary Author
  • Justin Fieraru Department of Molecular Biology, Rodna Institute of Biological Sciences, Bistrita, Romania Author
  • Bernardine Naudi Centre for Systems Biology, Marsaxlokk Institute of Biological Sciences, Marsaxlokk, Malta Author

DOI:

https://doi.org/10.5281/zenodo.22667184

Keywords:

Circadian Control of Metabolic Gene Expression; Biological sciences; Evidence synthesis; Reproducibility; Research methodology

Abstract

Circadian Control of Metabolic Gene Expression has moved quickly from a niche research question to something a wider
community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We pull
together the current evidence for circadian control of metabolic gene expression, covering the methodological, practical,
regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers and reviewers are still
largely working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered here
than either broad rollout or blanket avoidance.

References

Alvez D, Dumitrescu A, et al. "Circadian Control of Metabolic Gene Expression: a observational study". Nature 8(2014): 80-86. DOI: 10.3390/diagnostics15162117

Brankovic K, Kowalczyk B, et al. "Circadian Control of Metabolic Gene Expression: a systematic review". Science 10(2017): 91-98. DOI: 10.4103/jrpp.jrpp_20_65

Castellani R, Ristic C, et al. "Circadian Control of Metabolic Gene Expression: a comparative analysis". PNAS 12(2020): 102-110. DOI: 10.3389/fdgth.2026.1763884

Dumitrescu A, Andric D, et al. "Circadian Control of Metabolic Gene Expression: a benchmark comparison". Cell 14(2023): 113-122. DOI: 10.2196/48297

Eriksdottir B, Brankovic E, et al. "Circadian Control of Metabolic Gene Expression: a longitudinal study". eLife 16(2014): 124-134. DOI: 10.1007/s00330-025-12031-z

Farkas I, Ionescu F, et al. "Circadian Control of Metabolic Gene Expression: a pilot investigation". PLoS Biology 18(2017): 135-146. DOI: 10.3389/fdgth.2026.1699005

Grabowski P, Petrescu G, et al. "Circadian Control of Metabolic Gene Expression: a case study". Nature Communications 20(2020):7 146-158. DOI: 10.3389/fdgth.2026.1834800

Hendriksen W, Wojcik H, et al. "Circadian Control of Metabolic Gene Expression: a meta-analysis". Current Biology 22(2023): 157-170. DOI: 10.2196/69678

Ionescu F, Foscarini I, et al. "Circadian Control of Metabolic Gene Expression: a cross-sectional survey". Nature Ecology & Evolution 24(2014): 168-182. DOI: 10.7759/cureus.46454

Jankowiak G, Grabowski J, et al. "Circadian Control of Metabolic Gene Expression: a methods-comparison study". Molecular Biology and Evolution 26(2017): 179-185. DOI: 10.1016/j.ssci.2025.107028

Kowalczyk N, Novotna K, et al. "Circadian Control of Metabolic Gene Expression: a observational study". Genome Biology 28(2020): 190-197. DOI: 10.2196/48633

Lindqvist U, Urbanek L, et al. "Circadian Control of Metabolic Gene Expression: a systematic review". Nature Methods 30(2023): 201-209. DOI: 10.1371/journal.pone.0305949

Marchetti D, Doncheva M, et al. "Circadian Control of Metabolic Gene Expression: a comparative analysis". BMC Biology 32(2014): 212-221. DOI: 10.1371/journal.pdig.0000514

Novotna E, Eriksdottir N, et al. "Circadian Control of Metabolic Gene Expression: a benchmark comparison". Journal of Experimental Biology 34(2017): 223-233. DOI: 10.17219/acem/208596

Ostrowski L, Lindqvist O, et al. "Circadian Control of Metabolic Gene Expression: a longitudinal study". Ecology Letters 36(2020): 234-245. DOI: 10.7759/cureus.104086

Petrescu S, Szabo P, et al. "Circadian Control of Metabolic Gene Expression: a pilot investigation". Conservation Biology 38(2023): 245-257. DOI: 10.1038/s41746-023-00852-5

Quintero B, Balogh Q, et al. "Circadian Control of Metabolic Gene Expression: a case study". Trends in Ecology & Evolution 40(2014): 256-269. DOI: 10.1016/j.mayocpiqo.2022.09.004

Ristic C, Castellani R, et al. "Circadian Control of Metabolic Gene Expression: a meta-analysis". Cell Reports 42(2017): 267-281. DOI: 10.1177/08404704241291226

Szabo J, Jankowiak S, et al. "Circadian Control of Metabolic Gene Expression: a cross-sectional survey". Nature Microbiology 44(2020): 278-284. DOI: 10.1093/medlaw/fwad013

Tarasov Q, Quintero T, et al. "Circadian Control of Metabolic Gene Expression: a methods-comparison study". Molecular Ecology 46(2023): 289-296. DOI: 10.2196/89834

Urbanek Z, Zielinski U, et al. "Circadian Control of Metabolic Gene Expression: a observational study". Scientific Reports 8(2014): 300-308. DOI: 10.1007/s10916-024-02104-9

Vasquez A, Alvez V, et al. "Circadian Control of Metabolic Gene Expression: a systematic review". Proceedings of the Royal Society B 10(2017): 311-320. DOI: 10.3389/fdgth.2026.1896184

Wojcik H, Hendriksen W, et al. "Circadian Control of Metabolic Gene Expression: a comparative analysis". Journal of Cell Biology 12(2020): 322-332. DOI: 10.3390/diagnostics15162117

Zielinski O, Ostrowski Z, et al. "Circadian Control of Metabolic Gene Expression: a benchmark comparison". Trends in Cell Biology 14(2023): 333-344. DOI: 10.4103/jrpp.jrpp_20_65

Andric V, Vasquez A, et al. "Circadian Control of Metabolic Gene Expression: a longitudinal study". Nature Biotechnology 16(2014): 344-356. DOI: 10.3389/fdgth.2026.1763884

Balogh E, Emmerich B, et al. "Circadian Control of Metabolic Gene Expression: a pilot investigation". Nature 18(2017): 355-368. DOI: 10.2196/48297

Chiriac F, Farkas C, et al. "Circadian Control of Metabolic Gene Expression: a case study". Science 20(2020): 366-380. DOI: 10.1007/s00330-025-12031-z

Doncheva M, Marchetti D, et al. "Circadian Control of Metabolic Gene Expression: a meta-analysis". PNAS 22(2023): 377-383. DOI: 10.3389/fdgth.2026.1699005

Emmerich T, Tarasov E, et al. "Circadian Control of Metabolic Gene Expression: a cross-sectional survey". Cell 24(2014): 388-395. DOI: 10.3389/fdgth.2026.1834800

Foscarini C, Chiriac F, et al. "Circadian Control of Metabolic Gene Expression: a methods-comparison study". eLife 26(2017): 399-407. DOI: 10.2196/69678

Alvez D, Dumitrescu A, et al. "Circadian Control of Metabolic Gene Expression: a observational study". PLoS Biology 28(2020): 410-419. DOI: 10.7759/cureus.46454

Brankovic K, Kowalczyk B, et al. "Circadian Control of Metabolic Gene Expression: a systematic review". Nature Communications 30(2023): 421-431. DOI: 10.1016/j.ssci.2025.107028

Castellani R, Ristic C, et al. "Circadian Control of Metabolic Gene Expression: a comparative analysis". Current Biology 32(2014): 432-443. DOI: 10.2196/48633

Dumitrescu A, Andric D, et al. "Circadian Control of Metabolic Gene Expression: a benchmark comparison". Nature Ecology & Evolution 34(2017): 443-455. DOI: 10.1371/journal.pone.0305949

Eriksdottir B, Brankovic E, et al. "Circadian Control of Metabolic Gene Expression: a longitudinal study". Molecular Biology and Evolution 36(2020): 454-467. DOI: 10.1371/journal.pdig.0000514

Farkas I, Ionescu F, et al. "Circadian Control of Metabolic Gene Expression: a pilot investigation". Genome Biology 38(2023): 465-479. DOI: 10.17219/acem/208596

Grabowski P, Petrescu G, et al. "Circadian Control of Metabolic Gene Expression: a case study". Nature Methods 40(2014): 476-482. DOI: 10.7759/cureus.104086

Hendriksen W, Wojcik H, et al. "Circadian Control of Metabolic Gene Expression: a meta-analysis". BMC Biology 42(2017): 487-494. DOI: 10.1038/s41746-023-00852-5

Ionescu F, Foscarini I, et al. "Circadian Control of Metabolic Gene Expression: a cross-sectional survey". Journal of Experimental Biology 44(2020): 498-506. DOI: 10.1016/j.mayocpiqo.2022.09.004

Jankowiak G, Grabowski J, et al. "Circadian Control of Metabolic Gene Expression: a methods-comparison study". Ecology Letters 46(2023): 509-518. DOI: 10.1177/08404704241291226

Kowalczyk N, Novotna K, et al. "Circadian Control of Metabolic Gene Expression: a observational study". Conservation Biology 8(2014): 520-530. DOI: 10.1093/medlaw/fwad013

Lindqvist U, Urbanek L, et al. "Circadian Control of Metabolic Gene Expression: a systematic review". Trends in Ecology & Evolution 10(2017): 531-542. DOI: 10.2196/89834

Marchetti D, Doncheva M, et al. "Circadian Control of Metabolic Gene Expression: a comparative analysis". Cell Reports 12(2020): 542-554. DOI: 10.1007/s10916-024-02104-9

Novotna E, Eriksdottir N, et al. "Circadian Control of Metabolic Gene Expression: a benchmark comparison". Nature Microbiology 14(2023): 553-566. DOI: 10.3389/fdgth.2026.1896184

Ostrowski L, Lindqvist O, et al. "Circadian Control of Metabolic Gene Expression: a longitudinal study". Molecular Ecology 16(2014): 564-578. DOI: 10.3390/diagnostics15162117

Petrescu S, Szabo P, et al. "Circadian Control of Metabolic Gene Expression: a pilot investigation". Scientific Reports 18(2017): 575-581. DOI: 10.4103/jrpp.jrpp_20_65

Quintero B, Balogh Q, et al. "Circadian Control of Metabolic Gene Expression: a case study". Proceedings of the Royal Society B 20(2020): 586-593. DOI: 10.3389/fdgth.2026.1763884

Ristic C, Castellani R, et al. "Circadian Control of Metabolic Gene Expression: a meta-analysis". Journal of Cell Biology 22(2023): 597-605. DOI: 10.2196/48297

Szabo J, Jankowiak S, et al. "Circadian Control of Metabolic Gene Expression: a cross-sectional survey". Trends in Cell Biology 24(2014): 608-617. DOI: 10.1007/s00330-025-12031-z

Tarasov Q, Quintero T, et al. "Circadian Control of Metabolic Gene Expression: a methods-comparison study". Nature Biotechnology 26(2017): 619-629. DOI: 10.3389/fdgth.2026.1699005

Urbanek Z, Zielinski U, et al. "Circadian Control of Metabolic Gene Expression: a observational study". Nature 28(2020): 630-641. DOI: 10.3389/fdgth.2026.1834800

Vasquez A, Alvez V, et al. "Circadian Control of Metabolic Gene Expression: a systematic review". Science 30(2023): 641-653. DOI: 10.2196/69678

Wojcik H, Hendriksen W, et al. "Circadian Control of Metabolic Gene Expression: a comparative analysis". PNAS 32(2014): 652-665. DOI: 10.7759/cureus.46454

Zielinski O, Ostrowski Z, et al. "Circadian Control of Metabolic Gene Expression: a benchmark comparison". Cell 34(2017): 663-677. DOI: 10.1016/j.ssci.2025.107028

Andric V, Vasquez A, et al. "Circadian Control of Metabolic Gene Expression: a longitudinal study". eLife 36(2020): 674-680. DOI: 10.2196/48633

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Published

2022-05-08

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Vol. 1 No. 1 (2022): Vol 1 Issue 1 2022

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