Antimicrobial Discovery From Underexplored Soil Actinomycetes: Rediscovery Rates and Screening Design

Authors

  • Emilie Dolezalova Department of Microbiology, Ceskolipsko Institute of Biological Sciences, Ceska Lipa, Czech Republic Author
  • Jakob-Maria Doppelhofer Department of Microbial Ecology, Kamptal Centre for Molecular Life Sciences, Langenlois, Austria Author
  • Aloys Lorang Department of Biochemistry, Our Valley Centre for Molecular Life Sciences, Vianden, Luxembourg Author

DOI:

https://doi.org/10.5281/zenodo.22667303

Keywords:

Antimicrobial Discovery From Underexplored Soil Actinomycetes; Biological sciences; Evidence synthesis; Reproducibility; Research methodology

Abstract

Antimicrobial Discovery From Underexplored Soil Actinomycetes has moved quickly from a niche research question to something
a wider community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We
pull together the current evidence for antimicrobial discovery from underexplored soil actinomycetes, covering the
methodological, practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers
and reviewers are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the
evidence gathered here than either broad rollout or blanket avoidance.

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Vasquez A, Alvez V, et al. "Antimicrobial Discovery From Underexplored Soil Actinomycetes: a systematic review". Science 30(2023): 641-653. DOI: 10.1371/journal.pone.0305949

Wojcik H, Hendriksen W, et al. "Antimicrobial Discovery From Underexplored Soil Actinomycetes: a comparative analysis". PNAS 32(2014): 652-665. DOI: 10.1371/journal.pdig.0000514

Zielinski O, Ostrowski Z, et al. "Antimicrobial Discovery From Underexplored Soil Actinomycetes: a benchmark comparison". Cell 34(2017): 663-677. DOI: 10.17219/acem/208596

Andric V, Vasquez A, et al. "Antimicrobial Discovery From Underexplored Soil Actinomycetes: a longitudinal study". eLife 36(2020): 674-680. DOI: 10.7759/cureus.104086

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Published

2023-02-15