Tissue Clearing for Whole-Organ Imaging: A Technical Note on Refractive Index Matching
DOI:
https://doi.org/10.5281/zenodo.22668062Keywords:
Tissue Clearing for Whole-Organ Imaging; Biological sciences; Evidence synthesis; Reproducibility; Research methodologyAbstract
Tissue Clearing for Whole-Organ Imaging has moved quickly from a niche research question to something a wider community can
now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We pull together the current
evidence for tissue clearing for whole-organ imaging, covering the methodological, practical, regulatory and cost angles, with an
eye on where practice has genuinely settled and where researchers and reviewers are still largely working it out for themselves.
Selective, context-specific adoption looks better supported by the evidence gathered here than either broad rollout or blanket
avoidance.
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