Senescent Cell Burden and Tissue Function: A Systematic Review of Intervention Studies in Model Organisms

Authors

  • Delmira Cotrim Centre for Ageing Research, Barroso Institute of Biological Sciences, Montalegre, Portugal Author
  • Lucien Larcheveque Department of Cell Biology, Dombes Laboratory for Ecology and Evolution, Villars-les-Dombes, France Author
  • Hilda Refalo Department of Biostatistics, Marsaxlokk Institute of Biological Sciences, Marsaxlokk, Malta Author

DOI:

https://doi.org/10.5281/zenodo.22668075

Keywords:

Senescent Cell Burden and Tissue Function; Biological sciences; Evidence synthesis; Reproducibility; Research methodology

Abstract

There is real interest in senescent cell burden and tissue function right now, and real uncertainty about exactly where it delivers
the most value. We pull together the current evidence for senescent cell burden and tissue function, covering the methodological,
practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers and reviewers
are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered
here than either broad rollout or blanket avoidance.

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Published

2024-05-16