Biosensors for Continuous Metabolite Monitoring in Bioreactors: Drift and Recalibration Intervals
DOI:
https://doi.org/10.5281/zenodo.22668099Keywords:
Biosensors for Continuous Metabolite Monitoring in Bioreactors; Biological sciences; Evidence synthesis; Reproducibility; Research methodologyAbstract
Biosensors for Continuous Metabolite Monitoring in Bioreactors has moved quickly from a niche research question to something
a wider community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We
pull together the current evidence for biosensors for continuous metabolite monitoring in bioreactors, covering the
methodological, practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers
and reviewers are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the
evidence gathered here than either broad rollout or blanket avoidance.
References
Alvez D, Dumitrescu A, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a observational study". Nature 8(2014): 80-86. DOI: 10.7759/cureus.104086
Brankovic K, Kowalczyk B, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a systematic review". Science 10(2017): 91-98. DOI: 10.1038/s41746-023-00852-5
Castellani R, Ristic C, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a comparative analysis". PNAS 12(2020): 102-110. DOI: 10.1016/j.mayocpiqo.2022.09.004
Dumitrescu A, Andric D, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a benchmark comparison". Cell 14(2023): 113-122. DOI: 10.1177/08404704241291226
Eriksdottir B, Brankovic E, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a longitudinal study". eLife 16(2014): 124-134. DOI: 10.1093/medlaw/fwad013
Farkas I, Ionescu F, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a pilot investigation". PLoS Biology 18(2017): 135-146. DOI: 10.2196/89834
Grabowski P, Petrescu G, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a case study". Nature Communications 20(2020): 146-158. DOI: 10.1007/s10916-024-02104-9
Hendriksen W, Wojcik H, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a meta-analysis". Current Biology 22(2023): 157-170. DOI: 10.3389/fdgth.2026.1896184
Ionescu F, Foscarini I, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a cross-sectional survey". Nature Ecology & Evolution 24(2014): 168-182. DOI:
3390/diagnostics15162117 10. Jankowiak G, Grabowski J, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a methods-comparison study". Molecular Biology and Evolution 26(2017): 179-185. DOI: 10.4103/jrpp.jrpp_20_65
Kowalczyk N, Novotna K, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a observational study". Genome Biology 28(2020): 190-197. DOI: 10.3389/fdgth.2026.1763884
Lindqvist U, Urbanek L, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a systematic review". Nature Methods 30(2023): 201-209. DOI: 10.2196/48297
Marchetti D, Doncheva M, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a comparative analysis". BMC Biology 32(2014): 212-221. DOI: 10.1007/s00330-025-12031-z
Novotna E, Eriksdottir N, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a benchmark comparison". Journal of Experimental Biology 34(2017): 223-233. DOI: 10.3389/fdgth.2026.1699005
Ostrowski L, Lindqvist O, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a longitudinal study". Ecology Letters 36(2020): 234-245. DOI: 10.3389/fdgth.2026.1834800
Petrescu S, Szabo P, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a pilot investigation". Conservation Biology 38(2023): 245-257. DOI: 10.2196/69678
Quintero B, Balogh Q, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a case study". Trends in Ecology & Evolution 40(2014): 256-269. DOI: 10.7759/cureus.46454
Ristic C, Castellani R, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a meta-analysis". Cell Reports 42(2017): 267-281. DOI: 10.1016/j.ssci.2025.107028
Szabo J, Jankowiak S, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a cross-sectional survey". Nature Microbiology 44(2020): 278-284. DOI: 10.2196/48633
Tarasov Q, Quintero T, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a methods-comparison study". Molecular Ecology 46(2023): 289-296. DOI: 10.1371/journal.pone.0305949
Urbanek Z, Zielinski U, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a observational study". Scientific Reports 8(2014): 300-308. DOI: 10.1371/journal.pdig.0000514
Vasquez A, Alvez V, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a systematic review". Proceedings of the Royal Society B 10(2017): 311-320. DOI: 10.17219/acem/208596
Wojcik H, Hendriksen W, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a comparative analysis". Journal of Cell Biology 12(2020): 322-332. DOI: 10.7759/cureus.104086
Zielinski O, Ostrowski Z, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a benchmark comparison". Trends in Cell Biology 14(2023): 333-344. DOI: 10.1038/s41746-023-00852-5
Andric V, Vasquez A, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a longitudinal study". Nature Biotechnology 16(2014): 344-356. DOI: 10.1016/j.mayocpiqo.2022.09.004
Balogh E, Emmerich B, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a pilot investigation". Nature 18(2017): 355-368. DOI: 10.1177/08404704241291226
Chiriac F, Farkas C, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a case study". Science 20(2020): 366-380. DOI: 10.1093/medlaw/fwad013
Doncheva M, Marchetti D, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a meta-analysis". PNAS 22(2023): 377-383. DOI: 10.2196/89834
Emmerich T, Tarasov E, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a cross-sectional survey". Cell 24(2014): 388-395. DOI: 10.1007/s10916-024-02104-9
Foscarini C, Chiriac F, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a methods-comparison study". eLife 26(2017): 399-407. DOI: 10.3389/fdgth.2026.1896184
Alvez D, Dumitrescu A, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a observational study". PLoS Biology 28(2020): 410-419. DOI: 10.3390/diagnostics15162117
Brankovic K, Kowalczyk B, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a systematic review". Nature Communications 30(2023): 421-431. DOI: 10.4103/jrpp.jrpp_20_65
Castellani R, Ristic C, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a comparative analysis". Current Biology 32(2014): 432-443. DOI: 10.3389/fdgth.2026.1763884
Dumitrescu A, Andric D, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a benchmark comparison". Nature Ecology & Evolution 34(2017): 443-455. DOI: 10.2196/48297
Eriksdottir B, Brankovic E, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a longitudinal study". Molecular Biology and Evolution 36(2020): 454-467. DOI: 10.1007/s00330-025-12031-z
Farkas I, Ionescu F, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a pilot investigation". Genome Biology 38(2023): 465-479. DOI: 10.3389/fdgth.2026.1699005
Grabowski P, Petrescu G, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a case study". Nature Methods 40(2014): 476-482. DOI: 10.3389/fdgth.2026.1834800
Hendriksen W, Wojcik H, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a meta-analysis". BMC Biology 42(2017): 487-494. DOI: 10.2196/69678
Ionescu F, Foscarini I, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a cross-sectional survey". Journal of Experimental Biology 44(2020): 498-506. DOI: 10.7759/cureus.46454
Jankowiak G, Grabowski J, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a methods-comparison study". Ecology Letters 46(2023): 509-518. DOI: 10.1016/j.ssci.2025.107028
Kowalczyk N, Novotna K, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a observational study". Conservation Biology 8(2014): 520-530. DOI: 10.2196/48633
Lindqvist U, Urbanek L, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a systematic review". Trends in Ecology & Evolution 10(2017): 531-542. DOI: 10.1371/journal.pone.0305949
Marchetti D, Doncheva M, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a comparative analysis". Cell Reports 12(2020): 542-554. DOI: 10.1371/journal.pdig.0000514
Novotna E, Eriksdottir N, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a benchmark comparison". Nature Microbiology 14(2023): 553-566. DOI: 10.17219/acem/208596
Ostrowski L, Lindqvist O, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a longitudinal study". Molecular Ecology 16(2014): 564-578. DOI: 10.7759/cureus.104086
Petrescu S, Szabo P, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a pilot investigation". Scientific Reports 18(2017): 575-581. DOI: 10.1038/s41746-023-00852-5
Quintero B, Balogh Q, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a case study". Proceedings of the Royal Society B 20(2020): 586-593. DOI: 10.1016/j.mayocpiqo.2022.09.004
Ristic C, Castellani R, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a meta-analysis". Journal of Cell Biology 22(2023): 597-605. DOI: 10.1177/08404704241291226
Szabo J, Jankowiak S, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a cross-sectional survey". Trends in Cell Biology 24(2014): 608-617. DOI: 10.1093/medlaw/fwad013
Tarasov Q, Quintero T, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a methods-comparison study". Nature Biotechnology 26(2017): 619-629. DOI: 10.2196/89834
Urbanek Z, Zielinski U, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a observational study". Nature 28(2020): 630-641. DOI: 10.1007/s10916-024-02104-9
Vasquez A, Alvez V, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a systematic review". Science 30(2023): 641-653. DOI: 10.3389/fdgth.2026.1896184
Wojcik H, Hendriksen W, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a comparative analysis". PNAS 32(2014): 652-665. DOI: 10.3390/diagnostics15162117
Zielinski O, Ostrowski Z, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a benchmark comparison". Cell 34(2017): 663-677. DOI: 10.4103/jrpp.jrpp_20_65
Andric V, Vasquez A, et al. "Biosensors for Continuous Metabolite Monitoring in Bioreactors: a longitudinal study". eLife 36(2020): 674-680. DOI: 10.3389/fdgth.2026.1763884
