Metabolic Modelling of Microbial Consortia: Predicting Cross-Feeding From Genomes Alone

Abstract

There is real interest in metabolic modelling of microbial consortia right now, and real uncertainty about exactly where it delivers
the most value. We pull together the current evidence for metabolic modelling of microbial consortia, covering the
methodological, practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers
and reviewers are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the
evidence gathered here than either broad rollout or blanket avoidance.