Organ-on-Chip Barrier Models for Absorption Studies: A Benchmark Against Static Culture

Authors

  • Lucien Cheverny Centre for Stem Cell Biology, Dombes Laboratory for Ecology and Evolution, Villars-les-Dombes, France Author
  • Jorrit Foppema Department of Biophysics, Gooi Institute of Biological Sciences, Hilversum, Netherlands Author
  • Daithi Hartnett Department of Cell Biology, Iveragh Institute of Biological Sciences, Cahersiveen, Ireland Author

DOI:

https://doi.org/10.5281/zenodo.22672621

Keywords:

Organ-on-Chip Barrier Models for Absorption Studies; Biological sciences; Evidence synthesis; Reproducibility; Research methodology

Abstract

Organ-on-Chip Barrier Models for Absorption Studies has moved quickly from a niche research question to something a wider
community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We pull
together the current evidence for organ-on-chip barrier models for absorption studies, covering the methodological, practical,
regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers and reviewers are still
largely working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered here
than either broad rollout or blanket avoidance.

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Published

2026-07-25