THE ROLE OF MICROBIOME IN CHRONIC RHINOSINUSITIS: IMPLICATIONS FOR PERSONALIZED TREARTMENT
Keywords:
Chronic Rhinosinusitis, Microbiome, Dysbiosis, Bacterial Populations,, Immune Response, Inflammation, Staphylococcus aureus, Pseudomonas aeruginosa, Probiotics, Antibiotics, Microbiota Transplantation, Personalized Treatment, Microbial Diversity, Immune Modulation, Targeted Therapies, Precision MedicineAbstract
Chronic rhinosinusitis (CRS) is a long-standing inflammation of nasal and sinus mucosa, which negatively impacts patient’s quality of life. The recent research emphasize the central position of the microbiome in CRS with focus on microbial dysbiosis, meaning an upheaval of the normal bacterial flora, which erroneously fuels immune system chaos and inflammation. In CRS, pathogens like Staphylococcus aureus and Pseudomonas aeruginosa are found that replace normal flora and cause chronic symptoms. The current review discusses how bacterial diversity and immune reactions relate to CRS pathophysiology. It also assesses anti Microbiome Therapy, which includes Probiotics antibiotics, and Fecal Microbiota Transplant that has promising role in modifying microbial disturbances and enhancing patient prognosis. Although these developments, challenges like inconsistency in microbiome data and problems in identifying causal bacteria staysDue to accurate and efficient metagenomics, molecular diagnosis, and personalized on-targeted therapy and gene therapy in the future, there will be better therapeutic strategy and quality of life in patients with CRS.
