Microfluidic Organ Models in Preclinical Screening: A Review of Standardisation Barriers

Authors

  • Davis Cirulis Centre for Biofabrication, Kuldiga Centre for Emerging Materials, Kuldiga, Latvia Author
  • Dominique-M Geerinck Centre for Microfabrication, Calestienne Centre for Emerging Materials, Couvin, Belgium Author
  • Ester Cuk Department of Standards, Zasavje Institute of Advanced Technology, Trbovlje, Slovenia Author

DOI:

https://doi.org/10.5281/zenodo.22673879

Keywords:

Microfluidic Organ Models in Preclinical Screening; Next-generation R&D; Evidence synthesis; Reproducibility; Research methodology

Abstract

Microfluidic Organ Models in Preclinical Screening has moved quickly from a niche engineering question to something a wider
community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We pull
together the current evidence for microfluidic organ models in preclinical screening, covering the methodological, practical,
regulatory and cost angles, with an eye on where practice has genuinely settled and where engineers and reviewers are still
largely working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered here
than either broad rollout or blanket avoidance.

References

Alvez D, Dumitrescu A, et al. "Microfluidic Organ Models in Preclinical Screening: a benchmark study". Nature 8(2014): 80-86. DOI: 10.1007/s10916-024-02104-9

Brankovic K, Kowalczyk B, et al. "Microfluidic Organ Models in Preclinical Screening: a systematic review". Science 10(2017): 91-98. DOI: 10.3389/fdgth.2026.1896184

Castellani R, Ristic C, et al. "Microfluidic Organ Models in Preclinical Screening: a comparative analysis". Nature Materials 12(2020): 102-110. DOI: 10.3390/diagnostics15162117

Dumitrescu A, Andric D, et al. "Microfluidic Organ Models in Preclinical Screening: a pilot demonstration". Advanced Materials 14(2023): 113-122. DOI: 10.4103/jrpp.jrpp_20_65

Eriksdottir B, Brankovic E, et al. "Microfluidic Organ Models in Preclinical Screening: a longitudinal field study". Nature Energy 16(2014): 124-134. DOI: 10.3389/fdgth.2026.1763884

Farkas I, Ionescu F, et al. "Microfluidic Organ Models in Preclinical Screening: a feasibility study". Nature Electronics 18(2017): 135-146. DOI: 10.2196/48297

Grabowski P, Petrescu G, et al. "Microfluidic Organ Models in Preclinical Screening: a case study". Nature Nanotechnology 20(2020): 146-158. DOI: 10.1007/s00330-025-12031-z

Hendriksen W, Wojcik H, et al. "Microfluidic Organ Models in Preclinical Screening: a meta-analysis". Joule 22(2023): 157-170. DOI: 10.3389/fdgth.2026.1699005

Ionescu F, Foscarini I, et al. "Microfluidic Organ Models in Preclinical Screening: a cross-platform survey". Energy & Environmental Science 24(2014): 168-182. DOI:

3389/fdgth.2026.1834800 10. Jankowiak G, Grabowski J, et al. "Microfluidic Organ Models in Preclinical Screening: a methods-comparison study". ACS Nano 26(2017): 179-185. DOI: 10.2196/69678

Kowalczyk N, Novotna K, et al. "Microfluidic Organ Models in Preclinical Screening: a benchmark study". Advanced Energy Materials 28(2020): 190-197. DOI: 10.7759/cureus.46454

Lindqvist U, Urbanek L, et al. "Microfluidic Organ Models in Preclinical Screening: a systematic review". Applied Physics Letters 30(2023): 201-209. DOI: 10.1016/j.ssci.2025.107028

Marchetti D, Doncheva M, et al. "Microfluidic Organ Models in Preclinical Screening: a comparative analysis". Journal of Applied Physics 32(2014): 212-221. DOI: 10.2196/48633

Novotna E, Eriksdottir N, et al. "Microfluidic Organ Models in Preclinical Screening: a pilot demonstration". IEEE Transactions on Industrial Electronics 34(2017): 223-233. DOI: 10.1371/journal.pone.0305949

Ostrowski L, Lindqvist O, et al. "Microfluidic Organ Models in Preclinical Screening: a longitudinal field study". IEEE Spectrum 36(2020): 234-245. DOI: 10.1371/journal.pdig.0000514

Petrescu S, Szabo P, et al. "Microfluidic Organ Models in Preclinical Screening: a feasibility study". Nature Communications 38(2023): 245-257. DOI: 10.17219/acem/208596

Quintero B, Balogh Q, et al. "Microfluidic Organ Models in Preclinical Screening: a case study". Science Robotics 40(2014): 256-269. DOI: 10.7759/cureus.104086

Ristic C, Castellani R, et al. "Microfluidic Organ Models in Preclinical Screening: a meta-analysis". Additive Manufacturing 42(2017): 267-281. DOI: 10.1038/s41746-023-00852-5

Szabo J, Jankowiak S, et al. "Microfluidic Organ Models in Preclinical Screening: a cross-platform survey". Acta Materialia 44(2020): 278-284. DOI: 10.1016/j.mayocpiqo.2022.09.004

Tarasov Q, Quintero T, et al. "Microfluidic Organ Models in Preclinical Screening: a methods-comparison study". npj Computational Materials 46(2023): 289-296. DOI: 10.1177/08404704241291226

Urbanek Z, Zielinski U, et al. "Microfluidic Organ Models in Preclinical Screening: a benchmark study". Research Policy 8(2014): 300-308. DOI: 10.1093/medlaw/fwad013

Vasquez A, Alvez V, et al. "Microfluidic Organ Models in Preclinical Screening: a systematic review". Technovation 10(2017): 311-320. DOI: 10.2196/89834

Wojcik H, Hendriksen W, et al. "Microfluidic Organ Models in Preclinical Screening: a comparative analysis". MRS Bulletin 12(2020): 322-332. DOI: 10.1007/s10916-024-02104-9

Zielinski O, Ostrowski Z, et al. "Microfluidic Organ Models in Preclinical Screening: a pilot demonstration". Nature Reviews Materials 14(2023): 333-344. DOI: 10.3389/fdgth.2026.1896184

Andric V, Vasquez A, et al. "Microfluidic Organ Models in Preclinical Screening: a longitudinal field study". Progress in Materials Science 16(2014): 344-356. DOI: 10.3390/diagnostics15162117

Balogh E, Emmerich B, et al. "Microfluidic Organ Models in Preclinical Screening: a feasibility study". Nature 18(2017): 355-368. DOI: 10.4103/jrpp.jrpp_20_65

Chiriac F, Farkas C, et al. "Microfluidic Organ Models in Preclinical Screening: a case study". Science 20(2020): 366-380. DOI: 10.3389/fdgth.2026.1763884

Doncheva M, Marchetti D, et al. "Microfluidic Organ Models in Preclinical Screening: a meta-analysis". Nature Materials 22(2023): 377-383. DOI: 10.2196/48297

Emmerich T, Tarasov E, et al. "Microfluidic Organ Models in Preclinical Screening: a cross-platform survey". Advanced Materials 24(2014): 388-395. DOI: 10.1007/s00330-025-12031-z

Foscarini C, Chiriac F, et al. "Microfluidic Organ Models in Preclinical Screening: a methods-comparison study". Nature Energy 26(2017): 399-407. DOI: 10.3389/fdgth.2026.1699005

Alvez D, Dumitrescu A, et al. "Microfluidic Organ Models in Preclinical Screening: a benchmark study". Nature Electronics 28(2020): 410-419. DOI: 10.3389/fdgth.2026.1834800

Brankovic K, Kowalczyk B, et al. "Microfluidic Organ Models in Preclinical Screening: a systematic review". Nature Nanotechnology 30(2023): 421-431. DOI: 10.2196/69678

Castellani R, Ristic C, et al. "Microfluidic Organ Models in Preclinical Screening: a comparative analysis". Joule 32(2014): 432-443. DOI: 10.7759/cureus.46454

Dumitrescu A, Andric D, et al. "Microfluidic Organ Models in Preclinical Screening: a pilot demonstration". Energy & Environmental Science 34(2017): 443-455. DOI: 10.1016/j.ssci.2025.107028

Eriksdottir B, Brankovic E, et al. "Microfluidic Organ Models in Preclinical Screening: a longitudinal field study". ACS Nano 36(2020): 454-467. DOI: 10.2196/48633

Farkas I, Ionescu F, et al. "Microfluidic Organ Models in Preclinical Screening: a feasibility study". Advanced Energy Materials 38(2023): 465-479. DOI: 10.1371/journal.pone.0305949

Grabowski P, Petrescu G, et al. "Microfluidic Organ Models in Preclinical Screening: a case study". Applied Physics Letters 40(2014): 476-482. DOI: 10.1371/journal.pdig.0000514

Hendriksen W, Wojcik H, et al. "Microfluidic Organ Models in Preclinical Screening: a meta-analysis". Journal of Applied Physics 42(2017): 487-494. DOI: 10.17219/acem/208596

Ionescu F, Foscarini I, et al. "Microfluidic Organ Models in Preclinical Screening: a cross-platform survey". IEEE Transactions on Industrial Electronics 44(2020): 498-506. DOI: 10.7759/cureus.104086

Jankowiak G, Grabowski J, et al. "Microfluidic Organ Models in Preclinical Screening: a methods-comparison study". IEEE Spectrum 46(2023): 509-518. DOI: 10.1038/s41746-023-00852-5

Kowalczyk N, Novotna K, et al. "Microfluidic Organ Models in Preclinical Screening: a benchmark study". Nature Communications 8(2014): 520-530. DOI: 10.1016/j.mayocpiqo.2022.09.004

Lindqvist U, Urbanek L, et al. "Microfluidic Organ Models in Preclinical Screening: a systematic review". Science Robotics 10(2017): 531-542. DOI: 10.1177/08404704241291226

Marchetti D, Doncheva M, et al. "Microfluidic Organ Models in Preclinical Screening: a comparative analysis". Additive Manufacturing 12(2020): 542-554. DOI: 10.1093/medlaw/fwad013

Novotna E, Eriksdottir N, et al. "Microfluidic Organ Models in Preclinical Screening: a pilot demonstration". Acta Materialia 14(2023): 553-566. DOI: 10.2196/89834

Ostrowski L, Lindqvist O, et al. "Microfluidic Organ Models in Preclinical Screening: a longitudinal field study". npj Computational Materials 16(2014): 564-578. DOI: 10.1007/s10916-024-02104-9

Petrescu S, Szabo P, et al. "Microfluidic Organ Models in Preclinical Screening: a feasibility study". Research Policy 18(2017): 575-581. DOI: 10.3389/fdgth.2026.1896184

Quintero B, Balogh Q, et al. "Microfluidic Organ Models in Preclinical Screening: a case study". Technovation 20(2020): 586-593. DOI: 10.3390/diagnostics15162117

Ristic C, Castellani R, et al. "Microfluidic Organ Models in Preclinical Screening: a meta-analysis". MRS Bulletin 22(2023): 597-605. DOI: 10.4103/jrpp.jrpp_20_65

Szabo J, Jankowiak S, et al. "Microfluidic Organ Models in Preclinical Screening: a cross-platform survey". Nature Reviews Materials 24(2014): 608-617. DOI: 10.3389/fdgth.2026.1763884

Tarasov Q, Quintero T, et al. "Microfluidic Organ Models in Preclinical Screening: a methods-comparison study". Progress in Materials Science 26(2017): 619-629. DOI: 10.2196/48297

Urbanek Z, Zielinski U, et al. "Microfluidic Organ Models in Preclinical Screening: a benchmark study". Nature 28(2020): 630-641. DOI: 10.1007/s00330-025-12031-z

Vasquez A, Alvez V, et al. "Microfluidic Organ Models in Preclinical Screening: a systematic review". Science 30(2023): 641-653. DOI: 10.3389/fdgth.2026.1699005

Wojcik H, Hendriksen W, et al. "Microfluidic Organ Models in Preclinical Screening: a comparative analysis". Nature Materials 32(2014): 652-665. DOI: 10.3389/fdgth.2026.1834800

Zielinski O, Ostrowski Z, et al. "Microfluidic Organ Models in Preclinical Screening: a pilot demonstration". Advanced Materials 34(2017): 663-677. DOI: 10.2196/69678

Andric V, Vasquez A, et al. "Microfluidic Organ Models in Preclinical Screening: a longitudinal field study". Nature Energy 36(2020): 674-680. DOI: 10.7759/cureus.46454

Downloads

Published

2025-04-16