Circadian Phase and Time-of-Day Effects in Cognitive Testing: A Review of an Ignored Confound
DOI:
https://doi.org/10.5281/zenodo.22680869Keywords:
Circadian Phase and Time-of-Day Effects in Cognitive Testing; Cognitive neuroscience; Neurofeedback; Evidence synthesis; Research methodologyAbstract
Circadian Phase and Time-of-Day Effects in Cognitive Testing has moved quickly from a niche scientific question to something a
wider community can now investigate with reasonably reliable tools, but the evidence behind it has not always kept pace. We pull
together the current evidence for circadian phase and time-of-day effects in cognitive testing, covering the methodological,
practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers and reviewers
are still largely working it out for themselves. Selective, context-specific pursuit looks better supported by the evidence gathered
here than either broad rollout or blanket avoidance.
References
Alvez D, Dumitrescu A, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a benchmark study". Nature Neuroscience 8(2014): 80-86. DOI: 10.1093/medlaw/fwad013
Brankovic K, Kowalczyk B, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a systematic review". Neuron 10(2017): 91-98. DOI: 10.2196/89834
Castellani R, Ristic C, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a comparative analysis". NeuroImage 12(2020): 102-110. DOI: 10.1007/s10916-024-02104-9
Dumitrescu A, Andric D, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a pilot demonstration". Nature Reviews Neuroscience 14(2023): 113-122. DOI: 10.3389/fdgth.2026.1896184
Eriksdottir B, Brankovic E, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a longitudinal field study". Journal of Neuroscience 16(2014): 124-134. DOI: 10.3390/diagnostics15162117
Farkas I, Ionescu F, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a feasibility study". Brain 18(2017): 135-146. DOI: 10.4103/jrpp.jrpp_20_65
Grabowski P, Petrescu G, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a case study". Biological Psychiatry 20(2020): 146-158. DOI: 10.3389/fdgth.2026.1763884
Hendriksen W, Wojcik H, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a meta-analysis". Cerebral Cortex 22(2023): 157-170. DOI: 10.2196/48297
Ionescu F, Foscarini I, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a cross-platform survey". Cognitive, Affective, & Behavioral Neuroscience 24(2014): 168-182. DOI:
1007/s00330-025-12031-z 10. Jankowiak G, Grabowski J, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a methods-comparison study". eLife 26(2017): 179-185. DOI: 10.3389/fdgth.2026.1699005
Kowalczyk N, Novotna K, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a benchmark study". PNAS 28(2020): 190-197. DOI: 10.3389/fdgth.2026.1834800
Lindqvist U, Urbanek L, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a systematic review". Nature Communications 30(2023): 201-209. DOI: 10.2196/69678 7
Marchetti D, Doncheva M, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a comparative analysis". Nature Human Behaviour 32(2014): 212-221. DOI: 10.7759/cureus.46454
Novotna E, Eriksdottir N, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a pilot demonstration". Cortex 34(2017): 223-233. DOI: 10.1016/j.ssci.2025.107028
Ostrowski L, Lindqvist O, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a longitudinal field study". Journal of Cognitive Neuroscience 36(2020): 234-245. DOI: 10.2196/48633
Petrescu S, Szabo P, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a feasibility study". Psychological Science 38(2023): 245-257. DOI: 10.1371/journal.pone.0305949
Quintero B, Balogh Q, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a case study". Trends in Cognitive Sciences 40(2014): 256-269. DOI: 10.1371/journal.pdig.0000514
Ristic C, Castellani R, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a meta-analysis". Trends in Neurosciences 42(2017): 267-281. DOI: 10.17219/acem/208596
Szabo J, Jankowiak S, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a cross-platform survey". Human Brain Mapping 44(2020): 278-284. DOI: 10.7759/cureus.104086
Tarasov Q, Quintero T, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a methods-comparison study". Neurobiology of Learning and Memory 46(2023): 289-296. DOI: 10.1038/s41746-023-00852-5
Urbanek Z, Zielinski U, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a benchmark study". Sleep 8(2014): 300-308. DOI: 10.1016/j.mayocpiqo.2022.09.004
Vasquez A, Alvez V, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a systematic review". NeuroImage: Clinical 10(2017): 311-320. DOI: 10.1177/08404704241291226
Wojcik H, Hendriksen W, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a comparative analysis". eNeuro 12(2020): 322-332. DOI: 10.1093/medlaw/fwad013
Zielinski O, Ostrowski Z, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a pilot demonstration". Cognition 14(2023): 333-344. DOI: 10.2196/89834
Andric V, Vasquez A, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a longitudinal field study". Nature Reviews Neurology 16(2014): 344-356. DOI: 10.1007/s10916-024-02104-9
Balogh E, Emmerich B, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a feasibility study". Nature Neuroscience 18(2017): 355-368. DOI: 10.3389/fdgth.2026.1896184
Chiriac F, Farkas C, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a case study". Neuron 20(2020): 366-380. DOI: 10.3390/diagnostics15162117
Doncheva M, Marchetti D, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a meta-analysis". NeuroImage 22(2023): 377-383. DOI: 10.4103/jrpp.jrpp_20_65
Emmerich T, Tarasov E, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a cross-platform survey". Nature Reviews Neuroscience 24(2014): 388-395. DOI: 10.3389/fdgth.2026.1763884
Foscarini C, Chiriac F, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a methods-comparison study". Journal of Neuroscience 26(2017): 399-407. DOI: 10.2196/48297
Alvez D, Dumitrescu A, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a benchmark study". Brain 28(2020): 410-419. DOI: 10.1007/s00330-025-12031-z
Brankovic K, Kowalczyk B, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a systematic review". Biological Psychiatry 30(2023): 421-431. DOI: 10.3389/fdgth.2026.1699005
Castellani R, Ristic C, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a comparative analysis". Cerebral Cortex 32(2014): 432-443. DOI: 10.3389/fdgth.2026.1834800
Dumitrescu A, Andric D, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a pilot demonstration". Cognitive, Affective, & Behavioral Neuroscience 34(2017): 443-455. DOI: 10.2196/69678
Eriksdottir B, Brankovic E, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a longitudinal field study". eLife 36(2020): 454-467. DOI: 10.7759/cureus.46454
Farkas I, Ionescu F, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a feasibility study". PNAS 38(2023): 465-479. DOI: 10.1016/j.ssci.2025.107028
Grabowski P, Petrescu G, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a case study". Nature Communications 40(2014): 476-482. DOI: 10.2196/48633
Hendriksen W, Wojcik H, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a meta-analysis". Nature Human Behaviour 42(2017): 487-494. DOI: 10.1371/journal.pone.0305949
Ionescu F, Foscarini I, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a cross-platform survey". Cortex 44(2020): 498-506. DOI: 10.1371/journal.pdig.0000514
Jankowiak G, Grabowski J, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a methods-comparison study". Journal of Cognitive Neuroscience 46(2023): 509-518. DOI: 10.17219/acem/208596
Kowalczyk N, Novotna K, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a benchmark study". Psychological Science 8(2014): 520-530. DOI: 10.7759/cureus.104086
Lindqvist U, Urbanek L, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a systematic review". Trends in Cognitive Sciences 10(2017): 531-542. DOI: 10.1038/s41746-023-00852-5
Marchetti D, Doncheva M, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a comparative analysis". Trends in Neurosciences 12(2020): 542-554. DOI: 10.1016/j.mayocpiqo.2022.09.004
Novotna E, Eriksdottir N, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a pilot demonstration". Human Brain Mapping 14(2023): 553-566. DOI: 10.1177/08404704241291226
Ostrowski L, Lindqvist O, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a longitudinal field study". Neurobiology of Learning and Memory 16(2014): 564-578. DOI: 10.1093/medlaw/fwad013
Petrescu S, Szabo P, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a feasibility study". Sleep 18(2017): 575-581. DOI: 10.2196/89834
Quintero B, Balogh Q, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a case study". NeuroImage: Clinical 20(2020): 586-593. DOI: 10.1007/s10916-024-02104-9
Ristic C, Castellani R, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a meta-analysis". eNeuro 22(2023): 597-605. DOI: 10.3389/fdgth.2026.1896184
Szabo J, Jankowiak S, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a cross-platform survey". Cognition 24(2014): 608-617. DOI: 10.3390/diagnostics15162117
Tarasov Q, Quintero T, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a methods-comparison study". Nature Reviews Neurology 26(2017): 619-629. DOI: 10.4103/jrpp.jrpp_20_65
Urbanek Z, Zielinski U, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a benchmark study". Nature Neuroscience 28(2020): 630-641. 10.3389/fdgth.2026.1763884
Vasquez A, Alvez V, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a systematic review". Neuron 30(2023): 641-653. DOI: 10.2196/48297
Wojcik H, Hendriksen W, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a comparative analysis". NeuroImage 32(2014): 652-665. DOI: 10.1007/s00330-025-12031-z
Zielinski O, Ostrowski Z, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a pilot demonstration". Nature Reviews Neuroscience 34(2017): 663-677. 10.3389/fdgth.2026.1699005
Andric V, Vasquez A, et al. "Circadian Phase and Time-of-Day Effects in Cognitive Testing: a longitudinal field study". Journal of Neuroscience 36(2020): 674-680. 10.3389/fdgth.2026.1834800

