Real-World Comparative Effectiveness Without Randomisation: Target Trial Emulation in Practice
DOI:
https://doi.org/10.5281/zenodo.22649301Keywords:
Real-World Comparative Effectiveness Without Randomisation;, Translational medicine; Evidence synthesis;, Clinical implementation; Health services researchAbstract
Real-World Comparative Effectiveness Without Randomisation is an area of active development in translational medicine, with
evidence that has accumulated unevenly across its component questions. We review the current evidence base for real-world
comparative effectiveness without randomisation, spanning analytical, clinical, implementation, governance, and economic
dimensions, focusing on where practice has converged and where it continues to vary, and set out the practical considerations
relevant to a service considering its adoption. We conclude that selective, context-specific use is best supported by the evidence
currently available, rather than uniform adoption or avoidance
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