Real-World Comparative Effectiveness Without Randomisation: Target Trial Emulation in Practice

Authors

  • Dario Ripamonti Centre for Real-World Evidence, Sannio Centre for Experimental Therapeutics, Benevento, Italy Author
  • Baptiste Beaugrand Department of Biostatistics, Artois Institute of Molecular Therapeutics, Arras, France Author
  • Seppe Vlaeminck Centre for Clinical Trials Methodology, Haspengouw Institute of Translational Medicine, Tongeren, Belgium Author

DOI:

https://doi.org/10.5281/zenodo.22649301

Keywords:

Real-World Comparative Effectiveness Without Randomisation;, Translational medicine; Evidence synthesis;, Clinical implementation; Health services research

Abstract

Real-World Comparative Effectiveness Without Randomisation is an area of active development in translational medicine, with
evidence that has accumulated unevenly across its component questions. We review the current evidence base for real-world
comparative effectiveness without randomisation, spanning analytical, clinical, implementation, governance, and economic
dimensions, focusing on where practice has converged and where it continues to vary, and set out the practical considerations
relevant to a service considering its adoption. We conclude that selective, context-specific use is best supported by the evidence
currently available, rather than uniform adoption or avoidance

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Published

2024-10-11

Issue

Vol. 3 No. 2 (2024): vol 3 issue 2 2024

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Articles

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How to Cite

Real-World Comparative Effectiveness Without Randomisation: Target Trial Emulation in Practice. (2024). Translational Medicine & Therapeutics Journal, 3(2), 92-100. https://doi.org/10.5281/zenodo.22649301