GLP-1 Receptor Agonist Repurposing Across Indications: Mechanism, Evidence and Trial Sequencing

Authors

  • Kristaps Rudzitis Department of Endocrinology, Sela Centre for Experimental Therapeutics, Bauska, Latvia Author
  • Ari Gudlaugsson Department of Clinical Pharmacology, Arnessysla Institute of Translational Medicine, Hveragerdi, Iceland Author
  • Anja Cvetkovski Centre for Clinical Trials Methodology, Pomoravlje Institute of Molecular Therapeutics, Jagodina, Serbia Author

DOI:

https://doi.org/10.5281/zenodo.22649327

Keywords:

GLP-1 Receptor Agonist Repurposing Across Indications;, Translational medicine; Evidence synthesis;, Clinical implementation; Health services research

Abstract

GLP-1 Receptor Agonist Repurposing Across Indications is an area of active development in translational medicine, with evidence
that has accumulated unevenly across its component questions. We review the current evidence base for glp-1 receptor agonist
repurposing across indications, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing on
where practice has converged and where it continues to vary, and set out the practical considerations relevant to a service
considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently available,
rather than uniform adoption or avoidance.

References

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Foscarini C, Chiriac F, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a health-economic analysis". Clin Cancer Res 26(2023): 399-407. DOI: 10.2196/48297

Alvez D, Dumitrescu A, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a systematic review". BMJ Open 28(2011): 410-419. DOI: 10.1007/s00330-025-12031-z

Brankovic K, Kowalczyk B, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a methodological appraisal". J Clin Epidemiol 30(2014): 421-431. DOI: 10.3389/fdgth.2026.1699005

Castellani R, Ristic C, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a multicentre analysis". Contemp Clin Trials 32(2017): 432-443. DOI: 10.3389/fdgth.2026.1834800

Dumitrescu A, Andric D, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a prospective cohort study". Ther Innov Regul Sci 34(2020): 443-455. DOI: 10.2196/69678

Eriksdottir B, Brankovic E, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a randomised evaluation". Br J Clin Pharmacol 36(2023): 454-467. DOI: 10.7759/cureus.46454

Farkas I, Ionescu F, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a consensus statement". PLoS Med 38(2011): 465-479. DOI: 10.1016/j.ssci.2025.107028

Grabowski P, Petrescu G, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a retrospective analysis". Lancet 40(2014): 476-482. DOI: 10.2196/48633

Hendriksen W, Wojcik H, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a validation study". N Engl J Med 42(2017): 487-494. DOI: 10.1371/journal.pone.0305949

Ionescu F, Foscarini I, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a scoping review". JAMA 44(2020): 498-506. DOI: 10.1371/journal.pdig.0000514

Jankowiak G, Grabowski J, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a health-economic analysis". Nat Med 46(2023): 509-518. DOI: 10.17219/acem/208596

Kowalczyk N, Novotna K, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a systematic review". Cell Rep Med 8(2011): 520-530. DOI: 10.7759/cureus.104086

Lindqvist U, Urbanek L, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a methodological appraisal". Clin Transl Sci 10(2014): 531-542. DOI: 10.1038/s41746-023-00852-5

Marchetti D, Doncheva M, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a multicentre analysis". Pharmacogenomics J 12(2017): 542-554. DOI: 10.1016/j.mayocpiqo.2022.09.004

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Ostrowski L, Lindqvist O, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a randomised evaluation". Drug Saf 16(2023): 564-578. DOI: 10.1093/medlaw/fwad013

Petrescu S, Szabo P, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a consensus statement". Ann Intern Med 18(2011): 575-581. DOI: 10.2196/89834

Quintero B, Balogh Q, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a retrospective analysis". BMC Med 20(2014): 586-593. DOI: 10.1007/s10916-024-02104-9

Ristic C, Castellani R, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a validation study". Sci Transl Med 22(2017): 597-605. DOI: 10.3389/fdgth.2026.1896184

Szabo J, Jankowiak S, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a scoping review". J Transl Med 24(2020): 608-617. DOI: 10.3390/diagnostics15162117

Tarasov Q, Quintero T, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a health-economic analysis". Clin Pharmacol Ther 26(2023): 619-629. DOI: 10.4103/jrpp.jrpp_20_65

Urbanek Z, Zielinski U, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a systematic review". Nat Rev Drug Discov 28(2011): 630-641. DOI: 10.3389/fdgth.2026.1763884

Vasquez A, Alvez V, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a methodological appraisal". Trials 30(2014): 641-653. DOI: 10.2196/48297

Wojcik H, Hendriksen W, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a multicentre analysis". Drug Discov Today 32(2017): 652-665. DOI: 10.1007/s00330-025-12031-z

Zielinski O, Ostrowski Z, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a prospective cohort study". Clin Cancer Res 34(2020): 663-677. DOI: 10.3389/fdgth.2026.1699005

Andric V, Vasquez A, et al. "GLP-1 Receptor Agonist Repurposing Across Indications: a randomised evaluation". BMJ Open 36(2023): 674-680. DOI: 10.3389/fdgth.2026.1834800

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Published

2025-02-11

How to Cite

GLP-1 Receptor Agonist Repurposing Across Indications: Mechanism, Evidence and Trial Sequencing. (2025). Translational Medicine & Therapeutics Journal, 4(1), 10-18. https://doi.org/10.5281/zenodo.22649327

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