Equitable Access to Advanced Therapy Medicinal Products Across Europe: Pricing, Capacity and Referral Distance
DOI:
https://doi.org/10.5281/zenodo.22649584Keywords:
Equitable Access to Advanced Therapy Medicinal Products Across Europe; Translational medicine; Evidence synthesis; Clinical implementation; Health services researchAbstract
Equitable Access to Advanced Therapy Medicinal Products Across Europe is an area of active development in translational
medicine, with evidence that has accumulated unevenly across its component questions. We review the current evidence base for
equitable access to advanced therapy medicinal products across europe, spanning analytical, clinical, implementation,
governance, and economic dimensions, focusing on where practice has converged and where it continues to vary, and set out the
practical considerations relevant to a service considering its adoption. We conclude that selective, context-specific use is best
supported by the evidence currently available, rather than uniform adoption or avoidance
References
Alvez D, Dumitrescu A, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a systematic review". J Transl Med 8(2011): 80-86. DOI: 10.1371/journal.pone.0305949
Brankovic K, Kowalczyk B, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a methodological appraisal". Clin Pharmacol Ther 10(2014): 91-98. DOI: 10.1371/journal.pdig.0000514
Castellani R, Ristic C, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a multicentre analysis". Nat Rev Drug Discov 12(2017): 102-110. DOI: 10.17219/acem/208596
Dumitrescu A, Andric D, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a prospective cohort study". Trials 14(2020): 113-122. DOI: 10.7759/cureus.104086
Eriksdottir B, Brankovic E, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a randomised evaluation". Drug Discov Today 16(2023): 124-134. DOI: 10.1038/s41746-023-00852-5
Farkas I, Ionescu F, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a consensus statement". Clin Cancer Res 18(2011): 135-146. DOI: 10.1016/j.mayocpiqo.2022.09.004
Grabowski P, Petrescu G, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a retrospective analysis". BMJ Open 20(2014): 146-158. DOI: 10.1177/08404704241291226
Hendriksen W, Wojcik H, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a validation study". J Clin Epidemiol 22(2017): 157-170. DOI: 10.1093/medlaw/fwad013
Ionescu F, Foscarini I, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a scoping review". Contemp Clin Trials 24(2020): 168-182. DOI: 10.2196/89834
Jankowiak G, Grabowski J, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a health-economic analysis". Ther Innov Regul Sci 26(2023): 179-185. DOI: 10.1007/s10916-024-02104-9
Kowalczyk N, Novotna K, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a systematic review". Br J Clin Pharmacol 28(2011): 190-197. DOI: 10.3389/fdgth.2026.1896184
Lindqvist U, Urbanek L, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a methodological appraisal". PLoS Med 30(2014): 201-209. DOI: 10.3390/diagnostics15162117
Marchetti D, Doncheva M, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a multicentre analysis". Lancet 32(2017): 212-221. DOI: 10.4103/jrpp.jrpp_20_65
Novotna E, Eriksdottir N, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a prospective cohort study". N Engl J Med 34(2020): 223-233. DOI: 10.3389/fdgth.2026.1763884
Ostrowski L, Lindqvist O, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a randomised evaluation". JAMA 36(2023): 234-245. DOI: 10.2196/48297
Petrescu S, Szabo P, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a consensus statement". Nat Med 38(2011): 245-257. DOI: 10.1007/s00330-025-12031-z
Quintero B, Balogh Q, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a retrospective analysis". Cell Rep Med 40(2014): 256-269. DOI: 10.3389/fdgth.2026.1699005
Ristic C, Castellani R, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a validation study". Clin Transl Sci 42(2017): 267-281. DOI: 10.3389/fdgth.2026.1834800
Szabo J, Jankowiak S, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a scoping review". Pharmacogenomics J 44(2020): 278-284. DOI: 10.2196/69678
Tarasov Q, Quintero T, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a health-economic analysis". Regul Toxicol Pharmacol 46(2023): 289-296. DOI: 10.7759/cureus.46454
Urbanek Z, Zielinski U, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a systematic review". Drug Saf 8(2011): 300-308. DOI: 10.1016/j.ssci.2025.107028
Vasquez A, Alvez V, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a methodological appraisal". Ann Intern Med 10(2014): 311-320. DOI: 10.2196/48633
Wojcik H, Hendriksen W, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a multicentre analysis". BMC Med 12(2017): 322-332. DOI: 10.1371/journal.pone.0305949
Zielinski O, Ostrowski Z, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a prospective cohort study". Sci Transl Med 14(2020): 333-344. DOI: 10.1371/journal.pdig.0000514
Andric V, Vasquez A, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a randomised evaluation". J Transl Med 16(2023): 344-356. DOI: 10.17219/acem/208596
Balogh E, Emmerich B, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a consensus statement". Clin Pharmacol Ther 18(2011): 355-368. DOI: 10.7759/cureus.104086
Chiriac F, Farkas C, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a retrospective analysis". Nat Rev Drug Discov 20(2014): 366-380. DOI: 10.1038/s41746-023-00852-5
Doncheva M, Marchetti D, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a validation study". Trials 22(2017): 377-383. DOI: 10.1016/j.mayocpiqo.2022.09.004
Emmerich T, Tarasov E, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a scoping review". Drug Discov Today 24(2020): 388-395. DOI: 10.1177/08404704241291226
Foscarini C, Chiriac F, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a health-economic analysis". Clin Cancer Res 26(2023): 399-407. DOI: 10.1093/medlaw/fwad013
Alvez D, Dumitrescu A, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a systematic review". BMJ Open 28(2011): 410-419. DOI: 10.2196/89834
Brankovic K, Kowalczyk B, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a methodological appraisal". J Clin Epidemiol 30(2014): 421-431. DOI: 10.1007/s10916-024-02104-9
Castellani R, Ristic C, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a multicentre analysis". Contemp Clin Trials 32(2017): 432-443. DOI: 10.3389/fdgth.2026.1896184
Dumitrescu A, Andric D, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a prospective cohort study". Ther Innov Regul Sci 34(2020): 443-455. DOI: 10.3390/diagnostics15162117
Eriksdottir B, Brankovic E, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a randomised evaluation". Br J Clin Pharmacol 36(2023): 454-467. DOI: 10.4103/jrpp.jrpp_20_65
Farkas I, Ionescu F, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a consensus statement". PLoS Med 38(2011): 465-479. DOI: 10.3389/fdgth.2026.1763884
Grabowski P, Petrescu G, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a retrospective analysis". Lancet 40(2014): 476-482. DOI: 10.2196/48297
Hendriksen W, Wojcik H, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a validation study". N Engl J Med 42(2017): 487-494. DOI: 10.1007/s00330-025-12031-z
Ionescu F, Foscarini I, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a scoping review". JAMA 44(2020): 498-506. DOI: 10.3389/fdgth.2026.1699005
Jankowiak G, Grabowski J, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a health-economic analysis". Nat Med 46(2023): 509-518. DOI: 10.3389/fdgth.2026.1834800
Kowalczyk N, Novotna K, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a systematic review". Cell Rep Med 8(2011): 520-530. DOI: 10.2196/69678
Lindqvist U, Urbanek L, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a methodological appraisal". Clin Transl Sci 10(2014): 531-542. DOI: 10.7759/cureus.46454
Marchetti D, Doncheva M, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a multicentre analysis". Pharmacogenomics J 12(2017): 542-554. DOI: 10.1016/j.ssci.2025.107028
Novotna E, Eriksdottir N, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a prospective cohort study". Regul Toxicol Pharmacol 14(2020): 553-566. DOI: 10.2196/48633
Ostrowski L, Lindqvist O, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a randomised evaluation". Drug Saf 16(2023): 564-578. DOI: 10.1371/journal.pone.0305949
Petrescu S, Szabo P, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a consensus statement". Ann Intern Med 18(2011): 575-581. DOI: 10.1371/journal.pdig.0000514
Quintero B, Balogh Q, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a retrospective analysis". BMC Med 20(2014): 586-593. DOI: 10.17219/acem/208596
Ristic C, Castellani R, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a validation study". Sci Transl Med 22(2017): 597-605. DOI: 10.7759/cureus.104086
Szabo J, Jankowiak S, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a scoping review". J Transl Med 24(2020): 608-617. DOI: 10.1038/s41746-023-00852-5
Tarasov Q, Quintero T, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a health-economic analysis". Clin Pharmacol Ther 26(2023): 619-629. DOI: 10.1016/j.mayocpiqo.2022.09.004
Urbanek Z, Zielinski U, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a systematic review". Nat Rev Drug Discov 28(2011): 630-641. DOI: 10.1177/08404704241291226
Vasquez A, Alvez V, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a methodological appraisal". Trials 30(2014): 641-653. DOI: 10.1093/medlaw/fwad013
Wojcik H, Hendriksen W, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a multicentre analysis". Drug Discov Today 32(2017): 652-665. DOI: 10.2196/89834
Zielinski O, Ostrowski Z, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a prospective cohort study". Clin Cancer Res 34(2020): 663-677. DOI: 10.1007/s10916-024-02104-9
Andric V, Vasquez A, et al. "Equitable Access to Advanced Therapy Medicinal Products Across Europe: a randomised evaluation". BMJ Open 36(2023): 674-680. DOI: 10.3389/fdgth.2026.1896184
