Preclinical Reproducibility in Therapeutic Target Papers: An Audit of Reporting Completeness
DOI:
https://doi.org/10.5281/zenodo.22648951Keywords:
Preclinical Reproducibility in Therapeutic Target Papers, Translational medicine; Evidence synthesis, Clinical implementation; Health services researchAbstract
Preclinical Reproducibility in Therapeutic Target Papers is an area of active development in translational medicine, with
evidence that has accumulated unevenly across its component questions. We review the current evidence base for preclinical
reproducibility in therapeutic target papers, spanning analytical, clinical, implementation, governance, and economic dimensions,
focusing on where practice has converged and where it continues to vary, and set out the practical considerations relevant to a
service considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently
available, rather than uniform adoption or avoidance.
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