Bispecific Antibody Cytokine Release in the First Cycle: Step-Up Dosing and Monitoring Burden
DOI:
https://doi.org/10.5281/zenodo.22648961Keywords:
Bispecific Antibody Cytokine Release in the First Cycle;, Translational medicine; Evidence synthesis;, Clinical implementation; Health services researchAbstract
Bispecific Antibody Cytokine Release in the First Cycle is an area of active development in translational medicine, with evidence
that has accumulated unevenly across its component questions. We review the current evidence base for bispecific antibody
cytokine release in the first cycle, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing
on where practice has converged and where it continues to vary, and set out the practical considerations relevant to a service
considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently available,
rather than uniform adoption or avoidance.
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