Tumour-Infiltrating Lymphocyte Therapy in Melanoma: A Case Series of Three Heavily Pretreated Patients

Authors

  • Salvador Trindade Department of Medical Oncology, Beira Baixa Institute of Translational Medicine, Castelo Branco, Portugal Author
  • Iva Zubcic Department of Cell and Gene Therapy, Podravina Centre for Experimental Therapeutics, Koprivnica, Croatia Author
  • Emese Kelemen-Vig Centre for Translational Immunology, Orseg Centre for Experimental Therapeutics, Szentgotthard, Hungary Author

DOI:

https://doi.org/10.5281/zenodo.22649271

Keywords:

Tumour-Infiltrating Lymphocyte Therapy in Melanoma, Translational medicine; Evidence synthesis, Clinical implementation; Health services research

Abstract

Tumour-Infiltrating Lymphocyte Therapy in Melanoma is an area of active development in translational medicine, with evidence
that has accumulated unevenly across its component questions. We review the current evidence base for tumour-infiltrating
lymphocyte therapy in melanoma, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing
on where practice has converged and where it continues to vary, and set out the practical considerations relevant to a service
considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently available,
rather than uniform adoption or avoidance

References

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Foscarini C, Chiriac F, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a health-economic analysis". Clin Cancer Res 26(2023): 399-407. DOI: 10.3390/diagnostics15162117

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Brankovic K, Kowalczyk B, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a methodological appraisal". J Clin Epidemiol 30(2014): 421-431. DOI: 10.3389/fdgth.2026.1763884

Castellani R, Ristic C, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a multicentre analysis". Contemp Clin Trials 32(2017): 432-443. DOI: 10.2196/48297

Dumitrescu A, Andric D, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a prospective cohort study". Ther Innov Regul Sci 34(2020): 443-455. DOI: 10.1007/s00330-025-12031-z

Eriksdottir B, Brankovic E, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a randomised evaluation". Br J Clin Pharmacol 36(2023): 454-467. DOI: 10.3389/fdgth.2026.1699005

Farkas I, Ionescu F, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a consensus statement". PLoS Med 38(2011): 465-479. DOI: 10.3389/fdgth.2026.1834800

Grabowski P, Petrescu G, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a retrospective analysis". Lancet 40(2014): 476-482. DOI: 10.2196/69678

Hendriksen W, Wojcik H, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a validation study". N Engl J Med 42(2017): 487-494. DOI: 10.7759/cureus.46454

Ionescu F, Foscarini I, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a scoping review". JAMA 44(2020): 498-506. DOI: 10.1016/j.ssci.2025.107028

Jankowiak G, Grabowski J, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a health-economic analysis". Nat Med 46(2023): 509-518. DOI: 10.2196/48633

Kowalczyk N, Novotna K, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a systematic review". Cell Rep Med 8(2011): 520-530. DOI: 10.1371/journal.pone.0305949

Lindqvist U, Urbanek L, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a methodological appraisal". Clin Transl Sci 10(2014): 531-542. DOI: 10.1371/journal.pdig.0000514

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Quintero B, Balogh Q, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a retrospective analysis". BMC Med 20(2014): 586-593. DOI: 10.1177/08404704241291226

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Szabo J, Jankowiak S, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a scoping review". J Transl Med 24(2020): 608-617. DOI: 10.2196/89834

Tarasov Q, Quintero T, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a health-economic analysis". Clin Pharmacol Ther 26(2023): 619-629. DOI: 10.1007/s10916-024-02104-9

Urbanek Z, Zielinski U, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a systematic review". Nat Rev Drug Discov 28(2011): 630-641. DOI: 10.3389/fdgth.2026.1896184

Vasquez A, Alvez V, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a methodological appraisal". Trials 30(2014): 641-653. DOI: 10.3390/diagnostics15162117

Wojcik H, Hendriksen W, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a multicentre analysis". Drug Discov Today 32(2017): 652-665. DOI: 10.4103/jrpp.jrpp_20_65

Zielinski O, Ostrowski Z, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a prospective cohort study". Clin Cancer Res 34(2020): 663-677. DOI: 10.3389/fdgth.2026.1763884

Andric V, Vasquez A, et al. "Tumour-Infiltrating Lymphocyte Therapy in Melanoma: a randomised evaluation". BMJ Open 36(2023): 674-680. DOI: 10.2196/48297

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Published

2024-05-11

How to Cite

Tumour-Infiltrating Lymphocyte Therapy in Melanoma: A Case Series of Three Heavily Pretreated Patients. (2024). Translational Medicine & Therapeutics Journal, 3(1), 46-54. https://doi.org/10.5281/zenodo.22649271

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