Translational Failure in Neurodegeneration: What Two Decades of Negative Trials Should Change About Target Selection
DOI:
https://doi.org/10.5281/zenodo.22649321Keywords:
Translational Failure in Neurodegeneration; Translational medicine;, Evidence synthesis; Clinical implementation, Health services researchAbstract
Translational Failure in Neurodegeneration is an area of active development in translational medicine, with evidence that has
accumulated unevenly across its component questions. We review the current evidence base for translational failure in
neurodegeneration, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing on where
practice has converged and where it continues to vary, and set out the practical considerations relevant to a service considering
its adoption. We conclude that selective, context-specific use is best supported by the evidence currently available, rather than
uniform adoption or avoidance.
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