Advanced Hemostatic Agents in trauma care - A cross-sectional study

Abstract

Introduction: Traumatic injuries present a global public health challenge, emphasizing the importance of effective bleeding management to improve patient outcomes. Advanced hemostatic agents (AHAs) offer promising alternatives to traditional methods, yet comprehensive research on their utilization, efficacy, and safety in trauma care is lacking. This study aims to evaluate the landscape of AHAs in trauma care, assessing efficacy, safety, adoption trends, and clinical practices to inform evidence-based guidelines and optimize patient care.
Materials and Methods: A cross-sectional study was conducted across multiple trauma centers, collecting data on patient demographics, injury characteristics, hemostatic agent usage, clinical outcomes, and hospital settings. Utilization rates, adoption trends, and safety outcomes were analyzed using descriptive statistics, time-series analysis, and regression modeling.
Results: Demographic analysis of 500 trauma patients revealed a predominance of males (70%) and blunt trauma (80%), with motor vehicle accidents being the leading cause. AHAs were utilized in 60% of cases, achieving hemostasis in 85% within the first hour. Significant reductions in transfusion requirements were observed with AHA use. Adverse events were rare, with thromboembolic events occurring in 2% of cases. Multivariable regression identified trauma severity, mechanism of injury, and time to treatment initiation as predictors of AHA utilization, while trauma severity, age, and type of AHA were predictors of clinical outcomes.
Conclusion: This study provides comprehensive insights into AHA utilization, efficacy, and safety in trauma care, informing evidence-based practice and guiding future research to optimize patient outcomes. The findings underscore the importance of tailored treatment strategies and standardized protocols in enhancing trauma care delivery.