PRRS-Resistant Pigs and the Regulatory Pathway: A Review of Evidence Requirements Across Jurisdictions

Authors

  • Aleksander Ivanusa Department of Livestock Biotechnology, Vipava Institute of Agricultural Biotechnology, Ajdovscina, Slovenia Author
  • Ilija Isakovic Centre for Regulatory Science, Banat Institute of Agricultural Biotechnology, Zrenjanin, Serbia Author
  • Laima Eimutis Centre for Veterinary Vaccines, Dainava Institute of Agricultural Biotechnology, Druskininkai, Lithuania Author

DOI:

https://doi.org/10.5281/zenodo.22666669

Keywords:

PRRS-Resistant Pigs and the Regulatory Pathway; Agricultural biotechnology; Gene editing; Evidence synthesis; Biosafety regulation

Abstract

There is real interest in prrs-resistant pigs and the regulatory pathway right now, and real uncertainty about exactly where it
delivers the most value. We pull together the current evidence for prrs-resistant pigs and the regulatory pathway, covering the
methodological, practical, regulatory and cost angles, with an eye on where practice has genuinely settled and where researchers
and regulators are still largely working it out for themselves. Selective, context-specific adoption looks better supported by the
evidence gathered here than either broad rollout or blanket avoidance.

References

Alvez D, Dumitrescu A, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a field trial". Plant Biotechnol J 8(2014): 80-86. DOI: 10.17219/acem/208596

Brankovic K, Kowalczyk B, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a systematic review". Theor Appl Genet 10(2017): 91-98. DOI: 10.7759/cureus.104086

Castellani R, Ristic C, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a confined-trial evaluation". Front Plant Sci 12(2020): 102-110. DOI: 10.1038/s41746-023-00852-5

Dumitrescu A, Andric D, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a benchmark comparison". Transgenic Res 14(2023): 113-122. DOI: 10.1016/j.mayocpiqo.2022.09.004

Eriksdottir B, Brankovic E, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a multi-generation study". GM Crops Food 16(2014): 124-134. DOI: 10.1177/08404704241291226

Farkas I, Ionescu F, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a pilot deployment". Plant Cell Rep 18(2017): 135-146. DOI: 10.1093/medlaw/fwad013

Grabowski P, Petrescu G, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a case study". Mol Plant 20(2020): 146-158. DOI: 10.2196/89834

Hendriksen W, Wojcik H, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a meta-analysis". J Exp Bot 22(2023): 157-170. DOI: 10.1007/s10916-024-02104-9

Ionescu F, Foscarini I, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a comparative trial". Crop Sci 24(2014): 168-182. DOI: 10.3389/fdgth.2026.1896184

Jankowiak G, Grabowski J, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a stakeholder-survey study". Agron J 26(2017): 179-185. DOI: 10.3390/diagnostics15162117

Kowalczyk N, Novotna K, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a field trial". Plant Physiol 28(2020): 190-197. DOI: 10.4103/jrpp.jrpp_20_65

Lindqvist U, Urbanek L, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a systematic review". New Phytol 30(2023): 201-209. DOI: 10.3389/fdgth.2026.1763884

Marchetti D, Doncheva M, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a confined-trial evaluation". Nat Biotechnol 32(2014): 212-221. DOI: 10.2196/48297

Novotna E, Eriksdottir N, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a benchmark comparison". Sci Rep 34(2017): 223-233. DOI: 10.1007/s00330-025-12031-z

Ostrowski L, Lindqvist O, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a multi-generation study". PLoS One 36(2020): 234-245. DOI: 10.3389/fdgth.2026.1699005

Petrescu S, Szabo P, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a pilot deployment". BMC Plant Biol 38(2023): 245-257. DOI: 10.3389/fdgth.2026.1834800

Quintero B, Balogh Q, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a case study". Biotechnol Adv 40(2014): 256-269. DOI: 10.2196/69678

Ristic C, Castellani R, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a meta-analysis". Plant Mol Biol 42(2017): 267-281. DOI: 10.7759/cureus.46454

Szabo J, Jankowiak S, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a comparative trial". Field Crops Res 44(2020): 278-284. DOI: 10.1016/j.ssci.2025.107028

Tarasov Q, Quintero T, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a stakeholder-survey study". Euphytica 46(2023): 289-296. DOI: 10.2196/48633

Urbanek Z, Zielinski U, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a field trial". Front Genome Ed 8(2014): 300-308. DOI: 10.1371/journal.pone.0305949

Vasquez A, Alvez V, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a systematic review". CRISPR J 10(2017): 311-320. DOI: 10.1371/journal.pdig.0000514

Wojcik H, Hendriksen W, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a confined-trial evaluation". Plant Cell 12(2020): 322-332. DOI: 10.17219/acem/208596

Zielinski O, Ostrowski Z, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a benchmark comparison". Trends Biotechnol 14(2023): 333-344. DOI: 10.7759/cureus.104086

Andric V, Vasquez A, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a multi-generation study". Plant Biotechnol J 16(2014): 344-356. DOI: 10.1038/s41746-023-00852-5

Balogh E, Emmerich B, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a pilot deployment". Theor Appl Genet 18(2017): 355-368. DOI: 10.1016/j.mayocpiqo.2022.09.004

Chiriac F, Farkas C, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a case study". Front Plant Sci 20(2020): 366-380. DOI: 10.1177/08404704241291226

Doncheva M, Marchetti D, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a meta-analysis". Transgenic Res 22(2023): 377-383. DOI: 10.1093/medlaw/fwad013

Emmerich T, Tarasov E, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a comparative trial". GM Crops Food 24(2014): 388-395. DOI: 10.2196/89834

Foscarini C, Chiriac F, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a stakeholder-survey study". Plant Cell Rep 26(2017): 399-407. DOI: 10.1007/s10916-024-02104-9

Alvez D, Dumitrescu A, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a field trial". Mol Plant 28(2020): 410-419. DOI: 10.3389/fdgth.2026.1896184

Brankovic K, Kowalczyk B, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a systematic review". J Exp Bot 30(2023): 421-431. DOI: 10.3390/diagnostics15162117

Castellani R, Ristic C, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a confined-trial evaluation". Crop Sci 32(2014): 432-443. DOI: 10.4103/jrpp.jrpp_20_65

Dumitrescu A, Andric D, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a benchmark comparison". Agron J 34(2017): 443-455. DOI: 10.3389/fdgth.2026.1763884

Eriksdottir B, Brankovic E, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a multi-generation study". Plant Physiol 36(2020): 454-467. DOI: 10.2196/48297

Farkas I, Ionescu F, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a pilot deployment". New Phytol 38(2023): 465-479. DOI: 10.1007/s00330-025-12031-z

Grabowski P, Petrescu G, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a case study". Nat Biotechnol 40(2014): 476-482. DOI: 10.3389/fdgth.2026.1699005

Hendriksen W, Wojcik H, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a meta-analysis". Sci Rep 42(2017): 487-494. DOI: 10.3389/fdgth.2026.1834800

Ionescu F, Foscarini I, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a comparative trial". PLoS One 44(2020): 498-506. DOI: 10.2196/69678

Jankowiak G, Grabowski J, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a stakeholder-survey study". BMC Plant Biol 46(2023): 509-518. DOI: 10.7759/cureus.46454

Kowalczyk N, Novotna K, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a field trial". Biotechnol Adv 8(2014): 520-530. DOI: 10.1016/j.ssci.2025.107028

Lindqvist U, Urbanek L, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a systematic review". Plant Mol Biol 10(2017): 531-542. DOI: 10.2196/48633

Marchetti D, Doncheva M, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a confined-trial evaluation". Field Crops Res 12(2020): 542-554. DOI: 10.1371/journal.pone.0305949

Novotna E, Eriksdottir N, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a benchmark comparison". Euphytica 14(2023): 553-566. DOI: 10.1371/journal.pdig.0000514

Ostrowski L, Lindqvist O, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a multi-generation study". Front Genome Ed 16(2014): 564-578. DOI: 10.17219/acem/208596

Petrescu S, Szabo P, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a pilot deployment". CRISPR J 18(2017): 575-581. DOI: 10.7759/cureus.104086

Quintero B, Balogh Q, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a case study". Plant Cell 20(2020): 586-593. DOI: 10.1038/s41746-023-00852-5

Ristic C, Castellani R, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a meta-analysis". Trends Biotechnol 22(2023): 597-605. DOI: 10.1016/j.mayocpiqo.2022.09.004

Szabo J, Jankowiak S, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a comparative trial". Plant Biotechnol J 24(2014): 608-617. DOI: 10.1177/08404704241291226

Tarasov Q, Quintero T, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a stakeholder-survey study". Theor Appl Genet 26(2017): 619-629. DOI: 10.1093/medlaw/fwad013

Urbanek Z, Zielinski U, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a field trial". Front Plant Sci 28(2020): 630-641. DOI: 10.2196/89834

Vasquez A, Alvez V, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a systematic review". Transgenic Res 30(2023): 641-653. DOI: 10.1007/s10916-024-02104-9

Wojcik H, Hendriksen W, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a confined-trial evaluation". GM Crops Food 32(2014): 652-665. DOI: 10.3389/fdgth.2026.1896184

Zielinski O, Ostrowski Z, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a benchmark comparison". Plant Cell Rep 34(2017): 663-677. DOI: 10.3390/diagnostics15162117

Andric V, Vasquez A, et al. "PRRS-Resistant Pigs and the Regulatory Pathway: a multi-generation study". Mol Plant 36(2020): 674-680. DOI: 10.4103/jrpp.jrpp_20_65

Downloads

Published

2024-07-01