Nematode Resistance Through Host-Induced Gene Silencing: Field Study of Efficacy and Yield Response

Authors

  • Basilisa Goicoechea Department of Nematology, Priorat Centre for Plant Genome Engineering, Falset, Spain Author
  • Hedvika Grahek Department of Plant Molecular Biology, Vipava Institute of Agricultural Biotechnology, Ajdovscina, Slovenia Author
  • Christakis-D Daskalakis-M Department of Agronomy, Argolis Institute of Agricultural Biotechnology, Argos, Greece Author

DOI:

https://doi.org/10.5281/zenodo.22666684

Keywords:

Nematode Resistance Through Host-Induced Gene Silencing; Agricultural biotechnology; Gene editing; Evidence synthesis; Biosafety regulation

Abstract

Nematode Resistance Through Host-Induced Gene Silencing has moved quickly from a research idea to something a working
breeding or production programme can actually use, but the evidence behind it has not always kept pace. We pull together the
current evidence for nematode resistance through host-induced gene silencing, covering the methodological, practical, regulatory
and cost angles, with an eye on where practice has genuinely settled and where researchers and regulators are still largely
working it out for themselves. Selective, context-specific adoption looks better supported by the evidence gathered here than either
broad rollout or blanket avoidance.

References

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Foscarini C, Chiriac F, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a stakeholder-survey study". Plant Cell Rep 26(2017): 399-407. DOI: 10.3389/fdgth.2026.1896184

Alvez D, Dumitrescu A, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a field trial". Mol Plant 28(2020): 410-419. DOI: 10.3390/diagnostics15162117

Brankovic K, Kowalczyk B, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a systematic review". J Exp Bot 30(2023): 421-431. DOI: 10.4103/jrpp.jrpp_20_65

Castellani R, Ristic C, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a confined-trial evaluation". Crop Sci 32(2014): 432-443. DOI: 10.3389/fdgth.2026.1763884

Dumitrescu A, Andric D, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a benchmark comparison". Agron J 34(2017): 443-455. DOI: 10.2196/48297

Eriksdottir B, Brankovic E, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a multi-generation study". Plant Physiol 36(2020): 454-467. DOI: 10.1007/s00330-025-12031-z

Farkas I, Ionescu F, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a pilot deployment". New Phytol 38(2023): 465-479. DOI: 10.3389/fdgth.2026.1699005

Grabowski P, Petrescu G, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a case study". Nat Biotechnol 40(2014): 476-482. DOI: 10.3389/fdgth.2026.1834800

Hendriksen W, Wojcik H, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a meta-analysis". Sci Rep 42(2017): 487-494. DOI: 10.2196/69678

Ionescu F, Foscarini I, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a comparative trial". PLoS One 44(2020): 498-506. DOI: 10.7759/cureus.46454

Jankowiak G, Grabowski J, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a stakeholder-survey study". BMC Plant Biol 46(2023): 509-518. DOI: 10.1016/j.ssci.2025.107028

Kowalczyk N, Novotna K, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a field trial". Biotechnol Adv 8(2014): 520-530. DOI: 10.2196/48633

Lindqvist U, Urbanek L, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a systematic review". Plant Mol Biol 10(2017): 531-542. DOI: 10.1371/journal.pone.0305949

Marchetti D, Doncheva M, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a confined-trial evaluation". Field Crops Res 12(2020): 542-554. DOI: 10.1371/journal.pdig.0000514

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Quintero B, Balogh Q, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a case study". Plant Cell 20(2020): 586-593. DOI: 10.1016/j.mayocpiqo.2022.09.004

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Vasquez A, Alvez V, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a systematic review". Transgenic Res 30(2023): 641-653. DOI: 10.3389/fdgth.2026.1896184

Wojcik H, Hendriksen W, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a confined-trial evaluation". GM Crops Food 32(2014): 652-665. DOI: 10.3390/diagnostics15162117

Zielinski O, Ostrowski Z, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a benchmark comparison". Plant Cell Rep 34(2017): 663-677. DOI: 10.4103/jrpp.jrpp_20_65

Andric V, Vasquez A, et al. "Nematode Resistance Through Host-Induced Gene Silencing: a multi-generation study". Mol Plant 36(2020): 674-680. DOI: 10.3389/fdgth.2026.1763884

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Published

2024-08-15

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Vol. 3 No. 2 (2024): vol 3 issue 2 2024

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