Lignin Modification for Digestibility in Forage Crops: Trade-Offs With Lodging and Pathogen Entry

Authors

  • Hortense Lambesc Department of Plant Biochemistry, Medoc Institute of Plant Science, Pauillac, France Author
  • Adrian Gerber-Wid Department of Plant Breeding, Bundner Herrschaft Centre for Plant Genome Engineering, Maienfeld, Switzerland Author
  • Achiel Eeckhout Department of Plant Pathology, Demer Valley Institute of Agricultural Biotechnology, Aarschot, Belgium Author

DOI:

https://doi.org/10.5281/zenodo.22666696

Keywords:

Lignin Modification for Digestibility in Forage Crops; Agricultural biotechnology; Gene editing; Evidence synthesis; Biosafety regulation

Abstract

Lignin Modification for Digestibility in Forage Crops has moved quickly from a research idea to something a working breeding or
production programme can actually use, but the evidence behind it has not always kept pace. We pull together the current
evidence for lignin modification for digestibility in forage crops, covering the methodological, practical, regulatory and cost
angles, with an eye on where practice has genuinely settled and where researchers and regulators are still largely working it out
for themselves. Selective, context-specific adoption looks better supported by the evidence gathered here than either broad rollout
or blanket avoidance

References

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Andric V, Vasquez A, et al. "Lignin Modification for Digestibility in Forage Crops: a multi-generation study". Plant Biotechnol J 16(2014): 344-356. DOI: 10.1093/medlaw/fwad013

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Doncheva M, Marchetti D, et al. "Lignin Modification for Digestibility in Forage Crops: a meta-analysis". Transgenic Res 22(2023): 377-383. DOI: 10.3389/fdgth.2026.1896184

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Foscarini C, Chiriac F, et al. "Lignin Modification for Digestibility in Forage Crops: a stakeholder-survey study". Plant Cell Rep 26(2017): 399-407. DOI: 10.4103/jrpp.jrpp_20_65

Alvez D, Dumitrescu A, et al. "Lignin Modification for Digestibility in Forage Crops: a field trial". Mol Plant 28(2020): 410-419. DOI: 10.3389/fdgth.2026.1763884

Brankovic K, Kowalczyk B, et al. "Lignin Modification for Digestibility in Forage Crops: a systematic review". J Exp Bot 30(2023): 421-431. DOI: 10.2196/48297

Castellani R, Ristic C, et al. "Lignin Modification for Digestibility in Forage Crops: a confined-trial evaluation". Crop Sci 32(2014): 432-443. DOI: 10.1007/s00330-025-12031-z

Dumitrescu A, Andric D, et al. "Lignin Modification for Digestibility in Forage Crops: a benchmark comparison". Agron J 34(2017): 443-455. DOI: 10.3389/fdgth.2026.1699005

Eriksdottir B, Brankovic E, et al. "Lignin Modification for Digestibility in Forage Crops: a multi-generation study". Plant Physiol 36(2020): 454-467. DOI: 10.3389/fdgth.2026.1834800

Farkas I, Ionescu F, et al. "Lignin Modification for Digestibility in Forage Crops: a pilot deployment". New Phytol 38(2023): 465-479. DOI: 10.2196/69678

Grabowski P, Petrescu G, et al. "Lignin Modification for Digestibility in Forage Crops: a case study". Nat Biotechnol 40(2014): 476-482. DOI: 10.7759/cureus.46454

Hendriksen W, Wojcik H, et al. "Lignin Modification for Digestibility in Forage Crops: a meta-analysis". Sci Rep 42(2017): 487-494. DOI: 10.1016/j.ssci.2025.107028

Ionescu F, Foscarini I, et al. "Lignin Modification for Digestibility in Forage Crops: a comparative trial". PLoS One 44(2020): 498-506. DOI: 10.2196/48633

Jankowiak G, Grabowski J, et al. "Lignin Modification for Digestibility in Forage Crops: a stakeholder-survey study". BMC Plant Biol 46(2023): 509-518. DOI: 10.1371/journal.pone.0305949

Kowalczyk N, Novotna K, et al. "Lignin Modification for Digestibility in Forage Crops: a field trial". Biotechnol Adv 8(2014): 520-530. DOI: 10.1371/journal.pdig.0000514

Lindqvist U, Urbanek L, et al. "Lignin Modification for Digestibility in Forage Crops: a systematic review". Plant Mol Biol 10(2017): 531-542. DOI: 10.17219/acem/208596

Marchetti D, Doncheva M, et al. "Lignin Modification for Digestibility in Forage Crops: a confined-trial evaluation". Field Crops Res 12(2020): 542-554. DOI: 10.7759/cureus.104086

Novotna E, Eriksdottir N, et al. "Lignin Modification for Digestibility in Forage Crops: a benchmark comparison". Euphytica 14(2023): 553-566. DOI: 10.1038/s41746-023-00852-5

Ostrowski L, Lindqvist O, et al. "Lignin Modification for Digestibility in Forage Crops: a multi-generation study". Front Genome Ed 16(2014): 564-578. DOI: 10.1016/j.mayocpiqo.2022.09.004

Petrescu S, Szabo P, et al. "Lignin Modification for Digestibility in Forage Crops: a pilot deployment". CRISPR J 18(2017): 575-581. DOI: 10.1177/08404704241291226

Quintero B, Balogh Q, et al. "Lignin Modification for Digestibility in Forage Crops: a case study". Plant Cell 20(2020): 586-593. DOI: 10.1093/medlaw/fwad013

Ristic C, Castellani R, et al. "Lignin Modification for Digestibility in Forage Crops: a meta-analysis". Trends Biotechnol 22(2023): 597-605. DOI: 10.2196/89834

Szabo J, Jankowiak S, et al. "Lignin Modification for Digestibility in Forage Crops: a comparative trial". Plant Biotechnol J 24(2014): 608-617. DOI: 10.1007/s10916-024-02104-9

Tarasov Q, Quintero T, et al. "Lignin Modification for Digestibility in Forage Crops: a stakeholder-survey study". Theor Appl Genet 26(2017): 619-629. DOI: 10.3389/fdgth.2026.1896184

Urbanek Z, Zielinski U, et al. "Lignin Modification for Digestibility in Forage Crops: a field trial". Front Plant Sci 28(2020): 630-641. DOI: 10.3390/diagnostics15162117

Vasquez A, Alvez V, et al. "Lignin Modification for Digestibility in Forage Crops: a systematic review". Transgenic Res 30(2023): 641-653. DOI: 10.4103/jrpp.jrpp_20_65

Wojcik H, Hendriksen W, et al. "Lignin Modification for Digestibility in Forage Crops: a confined-trial evaluation". GM Crops Food 32(2014): 652-665. DOI: 10.3389/fdgth.2026.1763884

Zielinski O, Ostrowski Z, et al. "Lignin Modification for Digestibility in Forage Crops: a benchmark comparison". Plant Cell Rep 34(2017): 663-677. DOI: 10.2196/48297

Andric V, Vasquez A, et al. "Lignin Modification for Digestibility in Forage Crops: a multi-generation study". Mol Plant 36(2020): 674-680. DOI: 10.1007/s00330-025-12031-z

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Published

2024-10-11