Gene Therapy in a Patient With Pre-Existing Vector Immunity: A Two-Case Series of Alternative Serotypes
DOI:
https://doi.org/10.5281/zenodo.22649434Keywords:
Gene Therapy in a Patient With Pre-Existing Vector Immunity, Translational medicine; Evidence synthesis;, Clinical implementation; Health services researchAbstract
Gene Therapy in a Patient With Pre-Existing Vector Immunity is an area of active development in translational medicine, with
evidence that has accumulated unevenly across its component questions. We review the current evidence base for gene therapy in
a patient with pre-existing vector immunity, spanning analytical, clinical, implementation, governance, and economic dimensions,
focusing on where practice has converged and where it continues to vary, and set out the practical considerations relevant to a
service considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently
available, rather than uniform adoption or avoidance.
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