Drug Repurposing From Real-World Prescribing Data: Signal Generation and Its False Positives
DOI:
https://doi.org/10.5281/zenodo.22648840Keywords:
Drug Repurposing From Real-World Prescribing Data;, Translational medicine; Evidence synthesis, Clinical implementation; Health services researchAbstract
Drug Repurposing From Real-World Prescribing Data is an area of active development in translational medicine, with evidence
that has accumulated unevenly across its component questions. We review the current evidence base for drug repurposing from
real-world prescribing data, spanning analytical, clinical, implementation, governance, and economic dimensions, focusing on
where practice has converged and where it continues to vary, and set out the practical considerations relevant to a service
considering its adoption. We conclude that selective, context-specific use is best supported by the evidence currently available,
rather than uniform adoption or avoidance
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